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COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France
OBJECTIVES: Strasbourg University Hospital faced an important COVID-19 first wave from early March 2020. We performed a longitudinal prospective cohort study to describe clinical and virological data, exposure history to COVID-19, and adherence to strict hygiene standards during the first pandemic w...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Masson SAS.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582228/ https://www.ncbi.nlm.nih.gov/pubmed/34775140 http://dx.doi.org/10.1016/j.idnow.2021.11.002 |
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author | Velay, Aurélie Gallais, Floriane Wendling, Marie-Josée Bayer, Sophie Reix, Nathalie Schneider, Anne Glady, Ludovic Collongues, Nicolas Lessinger, Jean-Marc Hansmann, Yves Kling-Pillitteri, Laurence De Sèze, Jérome Gonzalez, Maria Schmidt-Mutter, Catherine Meyer, Nicolas Fafi-Kremer, Samira |
author_facet | Velay, Aurélie Gallais, Floriane Wendling, Marie-Josée Bayer, Sophie Reix, Nathalie Schneider, Anne Glady, Ludovic Collongues, Nicolas Lessinger, Jean-Marc Hansmann, Yves Kling-Pillitteri, Laurence De Sèze, Jérome Gonzalez, Maria Schmidt-Mutter, Catherine Meyer, Nicolas Fafi-Kremer, Samira |
author_sort | Velay, Aurélie |
collection | PubMed |
description | OBJECTIVES: Strasbourg University Hospital faced an important COVID-19 first wave from early March 2020. We performed a longitudinal prospective cohort study to describe clinical and virological data, exposure history to COVID-19, and adherence to strict hygiene standards during the first pandemic wave in 1497 workers undergoing a SARS-CoV-2 serological test at our hospital, with a follow up of serology result three months later. PATIENTS AND METHODS: A total of 1497 patients were enrolled from April 6 to May 7, 2020. Antibody response to SARS-CoV-2 was measured, and COVID-19 exposure routes were analyzed according to SARS-CoV-2 serological status. RESULTS: A total of 515 patients (34.4%) were seropositive, mainly medical students (13.2%) and assistant nurses (12.0%). A history of COVID-19 exposure in a professional and/or private setting was mentioned by 83.1% of seropositive subjects (P < 0.05; odds ratio [OR]: 2.5; 95% confidence interval [CI]: 1.8–3.4). COVID-19 exposure factors associated with seropositive status were non-professional exposure (OR: 1.9, 95% CI: 1.3–2.7), especially outside the immediate family circle (OR: 2.2, 95% CI: 1.2–3.9) and contact with a COVID-19 patient (OR: 1.6; 95% CI: 1.1–2.2). Among professionally exposed workers, systematic adherence to strict hygiene standards was well observed, except for the use of a surgical mask (P < 0.05, OR: 1.9, 95% CI: 1.3–2.8). Of those who reported occasionally or never wearing a surgical mask, nurses (25.7%), assistant nurses (16.2%), and medical students (11.7%) were predominant. CONCLUSION: Infection of staff members during the first pandemic wave in our hospital occurred after both professional and private COVID-19 exposure, underlining the importance of continuous training in strict hygiene standards. |
format | Online Article Text |
id | pubmed-8582228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Masson SAS. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85822282021-11-12 COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France Velay, Aurélie Gallais, Floriane Wendling, Marie-Josée Bayer, Sophie Reix, Nathalie Schneider, Anne Glady, Ludovic Collongues, Nicolas Lessinger, Jean-Marc Hansmann, Yves Kling-Pillitteri, Laurence De Sèze, Jérome Gonzalez, Maria Schmidt-Mutter, Catherine Meyer, Nicolas Fafi-Kremer, Samira Infect Dis Now Original Article OBJECTIVES: Strasbourg University Hospital faced an important COVID-19 first wave from early March 2020. We performed a longitudinal prospective cohort study to describe clinical and virological data, exposure history to COVID-19, and adherence to strict hygiene standards during the first pandemic wave in 1497 workers undergoing a SARS-CoV-2 serological test at our hospital, with a follow up of serology result three months later. PATIENTS AND METHODS: A total of 1497 patients were enrolled from April 6 to May 7, 2020. Antibody response to SARS-CoV-2 was measured, and COVID-19 exposure routes were analyzed according to SARS-CoV-2 serological status. RESULTS: A total of 515 patients (34.4%) were seropositive, mainly medical students (13.2%) and assistant nurses (12.0%). A history of COVID-19 exposure in a professional and/or private setting was mentioned by 83.1% of seropositive subjects (P < 0.05; odds ratio [OR]: 2.5; 95% confidence interval [CI]: 1.8–3.4). COVID-19 exposure factors associated with seropositive status were non-professional exposure (OR: 1.9, 95% CI: 1.3–2.7), especially outside the immediate family circle (OR: 2.2, 95% CI: 1.2–3.9) and contact with a COVID-19 patient (OR: 1.6; 95% CI: 1.1–2.2). Among professionally exposed workers, systematic adherence to strict hygiene standards was well observed, except for the use of a surgical mask (P < 0.05, OR: 1.9, 95% CI: 1.3–2.8). Of those who reported occasionally or never wearing a surgical mask, nurses (25.7%), assistant nurses (16.2%), and medical students (11.7%) were predominant. CONCLUSION: Infection of staff members during the first pandemic wave in our hospital occurred after both professional and private COVID-19 exposure, underlining the importance of continuous training in strict hygiene standards. Elsevier Masson SAS. 2022-02 2021-11-11 /pmc/articles/PMC8582228/ /pubmed/34775140 http://dx.doi.org/10.1016/j.idnow.2021.11.002 Text en © 2021 Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Velay, Aurélie Gallais, Floriane Wendling, Marie-Josée Bayer, Sophie Reix, Nathalie Schneider, Anne Glady, Ludovic Collongues, Nicolas Lessinger, Jean-Marc Hansmann, Yves Kling-Pillitteri, Laurence De Sèze, Jérome Gonzalez, Maria Schmidt-Mutter, Catherine Meyer, Nicolas Fafi-Kremer, Samira COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France |
title | COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France |
title_full | COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France |
title_fullStr | COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France |
title_full_unstemmed | COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France |
title_short | COVID-19 exposure in SARS-CoV-2-seropositive hospital staff members during the first pandemic wave at Strasbourg University Hospital, France |
title_sort | covid-19 exposure in sars-cov-2-seropositive hospital staff members during the first pandemic wave at strasbourg university hospital, france |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582228/ https://www.ncbi.nlm.nih.gov/pubmed/34775140 http://dx.doi.org/10.1016/j.idnow.2021.11.002 |
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