Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility

Aged males disproportionately succumb to increased COVID-19 severity, hospitalization, and mortality compared to females. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) facilitate SARS-CoV-2 viral entry and may have sexually dimorphic regulation. As viral load...

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Autores principales: Viveiros, Anissa, Gheblawi, Mahmoud, Aujla, Preetinder K., Sosnowski, Deanna K., Seubert, John M., Kassiri, Zamaneh, Oudit, Gavin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582230/
https://www.ncbi.nlm.nih.gov/pubmed/34774871
http://dx.doi.org/10.1016/j.yjmcc.2021.11.003
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author Viveiros, Anissa
Gheblawi, Mahmoud
Aujla, Preetinder K.
Sosnowski, Deanna K.
Seubert, John M.
Kassiri, Zamaneh
Oudit, Gavin Y.
author_facet Viveiros, Anissa
Gheblawi, Mahmoud
Aujla, Preetinder K.
Sosnowski, Deanna K.
Seubert, John M.
Kassiri, Zamaneh
Oudit, Gavin Y.
author_sort Viveiros, Anissa
collection PubMed
description Aged males disproportionately succumb to increased COVID-19 severity, hospitalization, and mortality compared to females. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) facilitate SARS-CoV-2 viral entry and may have sexually dimorphic regulation. As viral load dictates disease severity, we investigated the expression, protein levels, and activity of ACE2 and TMPRSS2. Our data reveal that aged males have elevated ACE2 in both mice and humans across organs. We report the first comparative study comprehensively investigating the impact of sex and age in murine and human levels of ACE2 and TMPRSS2, to begin to elucidate the sex bias in COVID-19 severity.
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spelling pubmed-85822302021-11-12 Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility Viveiros, Anissa Gheblawi, Mahmoud Aujla, Preetinder K. Sosnowski, Deanna K. Seubert, John M. Kassiri, Zamaneh Oudit, Gavin Y. J Mol Cell Cardiol Article Aged males disproportionately succumb to increased COVID-19 severity, hospitalization, and mortality compared to females. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) facilitate SARS-CoV-2 viral entry and may have sexually dimorphic regulation. As viral load dictates disease severity, we investigated the expression, protein levels, and activity of ACE2 and TMPRSS2. Our data reveal that aged males have elevated ACE2 in both mice and humans across organs. We report the first comparative study comprehensively investigating the impact of sex and age in murine and human levels of ACE2 and TMPRSS2, to begin to elucidate the sex bias in COVID-19 severity. Elsevier Ltd. 2022-03 2021-11-11 /pmc/articles/PMC8582230/ /pubmed/34774871 http://dx.doi.org/10.1016/j.yjmcc.2021.11.003 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Viveiros, Anissa
Gheblawi, Mahmoud
Aujla, Preetinder K.
Sosnowski, Deanna K.
Seubert, John M.
Kassiri, Zamaneh
Oudit, Gavin Y.
Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility
title Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility
title_full Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility
title_fullStr Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility
title_full_unstemmed Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility
title_short Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility
title_sort sex- and age-specific regulation of ace2: insights into severe covid-19 susceptibility
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582230/
https://www.ncbi.nlm.nih.gov/pubmed/34774871
http://dx.doi.org/10.1016/j.yjmcc.2021.11.003
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