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Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection
SIMPLE SUMMARY: We analyzed the data from 1952 patients with stage I colorectal cancer to evaluate the risk factors for recurrence and survival rates. In the entire cohort, the recurrence rate was 4.6%. There were some differences in the risk factors for recurrence between colon and rectal cancer in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582375/ https://www.ncbi.nlm.nih.gov/pubmed/34771458 http://dx.doi.org/10.3390/cancers13215294 |
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author | Jung, Hye-Sol Ryoo, Seung-Bum Lim, Han-Ki Kim, Min Jung Moon, Sang Hui Park, Ji Won Jeong, Seung-Yong Park, Kyu Joo |
author_facet | Jung, Hye-Sol Ryoo, Seung-Bum Lim, Han-Ki Kim, Min Jung Moon, Sang Hui Park, Ji Won Jeong, Seung-Yong Park, Kyu Joo |
author_sort | Jung, Hye-Sol |
collection | PubMed |
description | SIMPLE SUMMARY: We analyzed the data from 1952 patients with stage I colorectal cancer to evaluate the risk factors for recurrence and survival rates. In the entire cohort, the recurrence rate was 4.6%. There were some differences in the risk factors for recurrence between colon and rectal cancer in stage I colorectal cancer. Left-sided tumors, T2, tumor size >5 cm, and lymphovascular invasion were independent risk factors of colon cancer recurrence. Male, preoperative carcinoembryonic antigen (CEA) ≥2.5 ng/mL, and harvested lymph nodes (LNs) <12 were independently associated with recurrence of rectal cancer. Even though patients with early-stage CRC underwent curative resection, survival sharply decreased in cases of recurrence. Our findings could suggest more aggressive surveillance for patients with an increased risk of recurrence. ABSTRACT: Recurrence can still occur even after radical resection of stage I colorectal cancer (CRC). This study aimed to identify subgroups with a high risk for recurrence in the stage I CRC. We retrospectively reviewed prospectively collected data of 1952 patients with stage I CRC after radical resection between 2002 and 2017 at our institute. 1398 (colon, 903 (64.6%), rectum, 495 (35.4%)) were eligible for analysis. We analyzed the risk factors for recurrence and survival. During the follow-up period (median: 59 months), 63 (4.6%) had a recurrence. The recurrence rate of rectal cancer was significantly higher than that of colon cancer (8.5% vs. 2.3%). Left-sided tumors, T2, tumor size >5 cm, and lymphovascular invasion were independent risk factors of colon cancer recurrence. Male, preoperative carcinoembryonic antigen (CEA) ≥2.5 ng/mL, and harvested lymph nodes (LNs) <12 were independently associated with recurrence of rectal cancer. Recurrence affected OS (5-year OS: 97.1% vs. 67.6%). Despite curative resection, survival sharply decreased with recurrence. The risk factors for recurrence were different between colon and rectal cancer. Patients with a higher risk for recurrence should be candidates for more aggressive surveillance, even in early-stage CRC. |
format | Online Article Text |
id | pubmed-8582375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85823752021-11-12 Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection Jung, Hye-Sol Ryoo, Seung-Bum Lim, Han-Ki Kim, Min Jung Moon, Sang Hui Park, Ji Won Jeong, Seung-Yong Park, Kyu Joo Cancers (Basel) Article SIMPLE SUMMARY: We analyzed the data from 1952 patients with stage I colorectal cancer to evaluate the risk factors for recurrence and survival rates. In the entire cohort, the recurrence rate was 4.6%. There were some differences in the risk factors for recurrence between colon and rectal cancer in stage I colorectal cancer. Left-sided tumors, T2, tumor size >5 cm, and lymphovascular invasion were independent risk factors of colon cancer recurrence. Male, preoperative carcinoembryonic antigen (CEA) ≥2.5 ng/mL, and harvested lymph nodes (LNs) <12 were independently associated with recurrence of rectal cancer. Even though patients with early-stage CRC underwent curative resection, survival sharply decreased in cases of recurrence. Our findings could suggest more aggressive surveillance for patients with an increased risk of recurrence. ABSTRACT: Recurrence can still occur even after radical resection of stage I colorectal cancer (CRC). This study aimed to identify subgroups with a high risk for recurrence in the stage I CRC. We retrospectively reviewed prospectively collected data of 1952 patients with stage I CRC after radical resection between 2002 and 2017 at our institute. 1398 (colon, 903 (64.6%), rectum, 495 (35.4%)) were eligible for analysis. We analyzed the risk factors for recurrence and survival. During the follow-up period (median: 59 months), 63 (4.6%) had a recurrence. The recurrence rate of rectal cancer was significantly higher than that of colon cancer (8.5% vs. 2.3%). Left-sided tumors, T2, tumor size >5 cm, and lymphovascular invasion were independent risk factors of colon cancer recurrence. Male, preoperative carcinoembryonic antigen (CEA) ≥2.5 ng/mL, and harvested lymph nodes (LNs) <12 were independently associated with recurrence of rectal cancer. Recurrence affected OS (5-year OS: 97.1% vs. 67.6%). Despite curative resection, survival sharply decreased with recurrence. The risk factors for recurrence were different between colon and rectal cancer. Patients with a higher risk for recurrence should be candidates for more aggressive surveillance, even in early-stage CRC. MDPI 2021-10-21 /pmc/articles/PMC8582375/ /pubmed/34771458 http://dx.doi.org/10.3390/cancers13215294 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jung, Hye-Sol Ryoo, Seung-Bum Lim, Han-Ki Kim, Min Jung Moon, Sang Hui Park, Ji Won Jeong, Seung-Yong Park, Kyu Joo Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection |
title | Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection |
title_full | Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection |
title_fullStr | Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection |
title_full_unstemmed | Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection |
title_short | Tumor Size >5 cm and Harvested LNs <12 Are the Risk Factors for Recurrence in Stage I Colon and Rectal Cancer after Radical Resection |
title_sort | tumor size >5 cm and harvested lns <12 are the risk factors for recurrence in stage i colon and rectal cancer after radical resection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582375/ https://www.ncbi.nlm.nih.gov/pubmed/34771458 http://dx.doi.org/10.3390/cancers13215294 |
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