Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer

SIMPLE SUMMARY: The presence of the sodium–iodide symporter (NIS) at the plasma membrane (PM) of differentiated thyroid cancer (DTC) cells is required for the successful use of radioiodine (RAI) therapy in these malignancies. However, NIS is frequently downregulated in malignant thyroid tissue, and...

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Detalles Bibliográficos
Autores principales: Faria, Márcia, Domingues, Rita, Bugalho, Maria João, Silva, Ana Luísa, Matos, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582450/
https://www.ncbi.nlm.nih.gov/pubmed/34771624
http://dx.doi.org/10.3390/cancers13215460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582450/
https://www.ncbi.nlm.nih.gov/pubmed/34771624
http://dx.doi.org/10.3390/cancers13215460

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