Cargando…

Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer

SIMPLE SUMMARY: The presence of the sodium–iodide symporter (NIS) at the plasma membrane (PM) of differentiated thyroid cancer (DTC) cells is required for the successful use of radioiodine (RAI) therapy in these malignancies. However, NIS is frequently downregulated in malignant thyroid tissue, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faria, Márcia, Domingues, Rita, Bugalho, Maria João, Silva, Ana Luísa, Matos, Paulo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582450/ https://www.ncbi.nlm.nih.gov/pubmed/34771624 http://dx.doi.org/10.3390/cancers13215460

Ejemplares similares

MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells
por: Faria, Márcia, et al.
Publicado: (2021)

Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas
por: Faria, Márcia, et al.
Publicado: (2016)

Effect of PAK Inhibition on Cell Mechanics Depends on Rac1
por: Mierke, Claudia Tanja, et al.
Publicado: (2020)

RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells
por: Faria, Márcia, et al.
Publicado: (2017)

CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors
por: Whitelaw, Jamie A., et al.
Publicado: (2019)

Glycosylation of Sodium/Iodide Symporter (NIS) Regulates Its Membrane Translocation and Radioiodine Uptake
por: Chung, Taemoon, et al.
Publicado: (2015)

Expression and significance of Rac1, Pak1 and Rock1 in gastric carcinoma2
por: Wu, Yong-jun, et al.
Publicado: (2014)

A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association
por: Seyama, Rie, et al.
Publicado: (2023)

Ezrin activation by LOK phosphorylation involves a PIP(2)-dependent wedge mechanism
por: Pelaseyed, Thaher, et al.
Publicado: (2017)

Correlation between chemotherapy resistance in osteosarcoma patients and PAK5 and Ezrin gene expression
por: Liu, Qian, et al.
Publicado: (2018)

A Trio-Rac1-PAK1 signaling axis drives invadopodia disassembly
por: Moshfegh, Yasmin, et al.
Publicado: (2014)

Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization
por: Erasmus, Jennifer C., et al.
Publicado: (2021)

Suppression of RAC1-driven malignant melanoma by Group A PAK inhibitors
por: Araiza-Olivera, Daniela, et al.
Publicado: (2017)

Induction of Sodium/Iodide Symporter (NIS) Expression and Radioiodine Uptake in Non-Thyroid Cancer Cells
por: Liu, Zhi, et al.
Publicado: (2012)

Liposome Reconstitution and Modulation of Recombinant Prenylated Human Rac1 by GEFs, GDI1 and Pak1
por: Zhang, Si-Cai, et al.
Publicado: (2014)

Viral Dose, Radioiodine Uptake, and Delayed Efflux in Adenovirus Mediated NIS Radiovirotherapy Correlates with Treatment Efficacy
por: Trujillo, Miguel A., et al.
Publicado: (2012)

FOXA1 Regulation Turns Benzamide HDACi Treatment Effect-Specific in BC, Promoting NIS Gene-Mediated Targeted Radioiodine Therapy
por: Rathod, Maitreyi, et al.
Publicado: (2020)

RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1
por: Meyer zum Büschenfelde, Uta, et al.
Publicado: (2018)

Evidence for a Novel Mechanism of the PAK1 Interaction with the Rho-GTPases Cdc42 and Rac
por: Shin, Yong Jae, et al.
Publicado: (2013)

Upregulation of PIP3-Dependent Rac Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
por: Qin, Jianbing, et al.
Publicado: (2009)

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis
por: Bastos, Ricardo Nunes, et al.
Publicado: (2012)

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation
por: Whalley, Helen J., et al.
Publicado: (2015)

Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats
por: Xu, Lingfei, et al.
Publicado: (2023)

Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway
por: Reinardy, Jessica L., et al.
Publicado: (2015)

A Steep Radioiodine Dose Response Scalable to Humans in Sodium Iodide Symporter (NIS) Mediated Radiovirotherapy for Prostate Cancer
por: Trujillo, Miguel A., et al.
Publicado: (2012)

Overexpression of Both Human Sodium Iodide Symporter (NIS) and BRG1-Bromodomain Synergistically Enhances Radioiodine Sensitivity by Stabilizing p53 through NPM1 Expression
por: Na, Juri, et al.
Publicado: (2023)

PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactions
por: Grebeňová, Dana, et al.
Publicado: (2019)

A Novel Chimeric Poxvirus Encoding hNIS Is Tumor-Tropic, Imageable, and Synergistic with Radioiodine to Sustain Colon Cancer Regression
por: Warner, Susanne G., et al.
Publicado: (2019)

TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells
por: Faria, Márcia, et al.
Publicado: (2020)

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination
por: Acosta, Maria I., et al.
Publicado: (2018)

ICAM-2 regulates vascular permeability and N-cadherin localization through ezrin-radixin-moesin (ERM) proteins and Rac-1 signalling
por: Amsellem, Valerie, et al.
Publicado: (2014)

Nonconserved miR‐608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase‐3 pathways by targeting the 3′‐UTRs of RAC2/BCL2L1 and the coding region of PAK4
por: Zhang, Xu, et al.
Publicado: (2019)

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches
por: Byrne, Kate M., et al.
Publicado: (2016)

Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells
por: Gopal, Shashi K., et al.
Publicado: (2016)

Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer
por: Kamai, Takao, et al.
Publicado: (2010)

Hypoxic induction of vasculogenic mimicry in hepatocellular carcinoma: role of HIF-1 α, RhoA/ROCK and Rac1/PAK signaling
por: Zhang, Ji-Gang, et al.
Publicado: (2020)

Effects of Different Exercise Training Protocols on Gene Expression of Rac1 and PAK1 in Healthy Rat Fast- and Slow-Type Muscles
por: Laine, Saara, et al.
Publicado: (2020)

Expansion of BCR/ABL1 (+) cells requires PAK2 but not PAK1
por: Edlinger, Leo, et al.
Publicado: (2017)

Inactivation of Src-to-Ezrin Pathway: A Possible Mechanism in the Ouabain-Mediated Inhibition of A549 Cell Migration
por: Shin, Hye Kyoung, et al.
Publicado: (2015)

Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk
por: Rosenfeldt, Hans, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_lt37ldpenmjtagljkh6msjdqf6