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New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of H3K27M-Mutant Diffuse Midline Glioma

SIMPLE SUMMARY: H3K27M-mutant diffuse midline glioma is a rare childhood cancer originating in midline brain structures. The H3K27M mutation substitutes an amino acid on histone H3 that promotes gene expression and tumor growth. This cancer has a dismal prognosis and requires new and better treatmen...

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Detalles Bibliográficos
Autores principales:	Argersinger, Davis P., Rivas, Sarah R., Shah, Ashish H., Jackson, Sadhana, Heiss, John D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582453/ https://www.ncbi.nlm.nih.gov/pubmed/34771443 http://dx.doi.org/10.3390/cancers13215280

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