Mismatch Repair Status in Patient-Derived Colorectal Cancer Organoids Does Not Affect Intrinsic Tumor Cell Sensitivity to Systemic Therapy

SIMPLE SUMMARY: The large majority of patients with metastatic colorectal cancer (mCRC) receive chemotherapy with or without targeted therapy. Tumors with a deficient DNA mismatch repair (dMMR) system respond poorly to systemic therapy and are associated with poor prognosis. However, it is unclear w...

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Detalles Bibliográficos
Autores principales: Küçükköse, Emre, Wensink, G. Emerens, Roelse, Celine M., van Schelven, Susanne J., Raats, Daniëlle A. E., Boj, Sylvia F., Koopman, Miriam, Laoukili, Jamila, Roodhart, Jeanine M. L., Kranenburg, Onno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582471/
https://www.ncbi.nlm.nih.gov/pubmed/34771595
http://dx.doi.org/10.3390/cancers13215434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582471/
https://www.ncbi.nlm.nih.gov/pubmed/34771595
http://dx.doi.org/10.3390/cancers13215434

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