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Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment

SIMPLE SUMMARY: The following review addresses the effects of cancer and cancer treatments on fertility and reproductive health, and reviews standard and novel fertility preservation options. This article presents a needs assessment focusing on disparities in access to care for the pediatric, adoles...

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Autores principales: Coker Appiah, Leslie, Fei, Yueyang Frances, Olsen, Mallery, Lindheim, Steven R., Puccetti, Diane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582476/
https://www.ncbi.nlm.nih.gov/pubmed/34771582
http://dx.doi.org/10.3390/cancers13215419
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author Coker Appiah, Leslie
Fei, Yueyang Frances
Olsen, Mallery
Lindheim, Steven R.
Puccetti, Diane M.
author_facet Coker Appiah, Leslie
Fei, Yueyang Frances
Olsen, Mallery
Lindheim, Steven R.
Puccetti, Diane M.
author_sort Coker Appiah, Leslie
collection PubMed
description SIMPLE SUMMARY: The following review addresses the effects of cancer and cancer treatments on fertility and reproductive health, and reviews standard and novel fertility preservation options. This article presents a needs assessment focusing on disparities in access to care for the pediatric, adolescent, and young adult (AYA) population to include cost, provider bias, inequitable referral patterns to reproductive specialists, and a lack of knowledge within the medical community regarding assisted reproductive technologies and reproductive health care in survivorship. The information presented in this article is targeted to oncologists, gynecologists, pediatric subspecialists, and primary care providers who care for this population and introduces areas for further research to address gaps in care and improve access for this population. ABSTRACT: Advancements in cancer screening and implementation of targeted treatments have significantly improved survival rates to 85% for pediatric and AYA survivors. Greater than 75% of survivors will live to experience the long-term adverse outcomes of cancer therapies, termed late effects (LE), that disrupt quality of life (QoL). Infertility and poor reproductive outcomes are significant disruptors of QoL in survivorship, affecting 12–88% of survivors who receive at-risk therapies. To mitigate risk, fertility preservation (FP) counseling is recommended as standard of care prior to gonadotoxic therapy. However, disparities in FP counseling, implementation of FP interventions, and screening for gynecologic late effects in survivorship persist. Barriers to care include a lack of provider and patient knowledge of the safety and breadth of current FP options, misconceptions about the duration of time required to implement FP therapies, cost, and health care team bias. Developing strategies to address barriers and implement established guidelines are necessary to ensure equity and improve quality of care across populations.
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spelling pubmed-85824762021-11-12 Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment Coker Appiah, Leslie Fei, Yueyang Frances Olsen, Mallery Lindheim, Steven R. Puccetti, Diane M. Cancers (Basel) Review SIMPLE SUMMARY: The following review addresses the effects of cancer and cancer treatments on fertility and reproductive health, and reviews standard and novel fertility preservation options. This article presents a needs assessment focusing on disparities in access to care for the pediatric, adolescent, and young adult (AYA) population to include cost, provider bias, inequitable referral patterns to reproductive specialists, and a lack of knowledge within the medical community regarding assisted reproductive technologies and reproductive health care in survivorship. The information presented in this article is targeted to oncologists, gynecologists, pediatric subspecialists, and primary care providers who care for this population and introduces areas for further research to address gaps in care and improve access for this population. ABSTRACT: Advancements in cancer screening and implementation of targeted treatments have significantly improved survival rates to 85% for pediatric and AYA survivors. Greater than 75% of survivors will live to experience the long-term adverse outcomes of cancer therapies, termed late effects (LE), that disrupt quality of life (QoL). Infertility and poor reproductive outcomes are significant disruptors of QoL in survivorship, affecting 12–88% of survivors who receive at-risk therapies. To mitigate risk, fertility preservation (FP) counseling is recommended as standard of care prior to gonadotoxic therapy. However, disparities in FP counseling, implementation of FP interventions, and screening for gynecologic late effects in survivorship persist. Barriers to care include a lack of provider and patient knowledge of the safety and breadth of current FP options, misconceptions about the duration of time required to implement FP therapies, cost, and health care team bias. Developing strategies to address barriers and implement established guidelines are necessary to ensure equity and improve quality of care across populations. MDPI 2021-10-28 /pmc/articles/PMC8582476/ /pubmed/34771582 http://dx.doi.org/10.3390/cancers13215419 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Coker Appiah, Leslie
Fei, Yueyang Frances
Olsen, Mallery
Lindheim, Steven R.
Puccetti, Diane M.
Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment
title Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment
title_full Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment
title_fullStr Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment
title_full_unstemmed Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment
title_short Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment
title_sort disparities in female pediatric, adolescent and young adult oncofertility: a needs assessment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582476/
https://www.ncbi.nlm.nih.gov/pubmed/34771582
http://dx.doi.org/10.3390/cancers13215419
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