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Molecular Mechanisms of Mitotane Action in Adrenocortical Cancer Based on In Vitro Studies

SIMPLE SUMMARY: Mitotane is the only approved drug for the treatment of advanced adrenocortical carcinoma and for postoperative adjuvant therapy. It is known that mitotane destroys the adrenal cortex impairing steroidogenesis, although its exact molecular mechanism is still unclear. However, confoun...

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Detalles Bibliográficos
Autores principales:	Lo Iacono, Marco, Puglisi, Soraya, Perotti, Paola, Saba, Laura, Petiti, Jessica, Giachino, Claudia, Reimondo, Giuseppe, Terzolo, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582505/ https://www.ncbi.nlm.nih.gov/pubmed/34771418 http://dx.doi.org/10.3390/cancers13215255

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