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Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension

Pulmonary arterial hypertension (PAH), group 1 pulmonary hypertension (PH), is a fatal disease that is characterized by vasoconstriction, increased pressure in the pulmonary arteries, and right heart failure. PAH can be described by abnormal vascular remodeling, hyperproliferation in the vasculature...

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Autores principales: Shihan, Mazen, Novoyatleva, Tatyana, Lehmeyer, Thilo, Sydykov, Akylbek, Schermuly, Ralph T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582672/
https://www.ncbi.nlm.nih.gov/pubmed/34769531
http://dx.doi.org/10.3390/ijerph182111009
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author Shihan, Mazen
Novoyatleva, Tatyana
Lehmeyer, Thilo
Sydykov, Akylbek
Schermuly, Ralph T.
author_facet Shihan, Mazen
Novoyatleva, Tatyana
Lehmeyer, Thilo
Sydykov, Akylbek
Schermuly, Ralph T.
author_sort Shihan, Mazen
collection PubMed
description Pulmonary arterial hypertension (PAH), group 1 pulmonary hypertension (PH), is a fatal disease that is characterized by vasoconstriction, increased pressure in the pulmonary arteries, and right heart failure. PAH can be described by abnormal vascular remodeling, hyperproliferation in the vasculature, endothelial cell dysfunction, and vascular tone dysregulation. The disease pathomechanisms, however, are as yet not fully understood at the molecular level. Purinergic receptors P2Y within the G-protein-coupled receptor family play a major role in fluid shear stress transduction, proliferation, migration, and vascular tone regulation in systemic circulation, but less is known about their contribution in PAH. Hence, studies that focus on purinergic signaling are of great importance for the identification of new therapeutic targets in PAH. Interestingly, the role of P2Y2 receptors has not yet been sufficiently studied in PAH, whereas the relevance of other P2Ys as drug targets for PAH was shown using specific agonists or antagonists. In this review, we will shed light on P2Y receptors and focus more on the P2Y2 receptor as a potential novel player in PAH and as a new therapeutic target for disease management.
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spelling pubmed-85826722021-11-12 Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension Shihan, Mazen Novoyatleva, Tatyana Lehmeyer, Thilo Sydykov, Akylbek Schermuly, Ralph T. Int J Environ Res Public Health Review Pulmonary arterial hypertension (PAH), group 1 pulmonary hypertension (PH), is a fatal disease that is characterized by vasoconstriction, increased pressure in the pulmonary arteries, and right heart failure. PAH can be described by abnormal vascular remodeling, hyperproliferation in the vasculature, endothelial cell dysfunction, and vascular tone dysregulation. The disease pathomechanisms, however, are as yet not fully understood at the molecular level. Purinergic receptors P2Y within the G-protein-coupled receptor family play a major role in fluid shear stress transduction, proliferation, migration, and vascular tone regulation in systemic circulation, but less is known about their contribution in PAH. Hence, studies that focus on purinergic signaling are of great importance for the identification of new therapeutic targets in PAH. Interestingly, the role of P2Y2 receptors has not yet been sufficiently studied in PAH, whereas the relevance of other P2Ys as drug targets for PAH was shown using specific agonists or antagonists. In this review, we will shed light on P2Y receptors and focus more on the P2Y2 receptor as a potential novel player in PAH and as a new therapeutic target for disease management. MDPI 2021-10-20 /pmc/articles/PMC8582672/ /pubmed/34769531 http://dx.doi.org/10.3390/ijerph182111009 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shihan, Mazen
Novoyatleva, Tatyana
Lehmeyer, Thilo
Sydykov, Akylbek
Schermuly, Ralph T.
Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_full Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_fullStr Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_full_unstemmed Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_short Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_sort role of the purinergic p2y2 receptor in pulmonary hypertension
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582672/
https://www.ncbi.nlm.nih.gov/pubmed/34769531
http://dx.doi.org/10.3390/ijerph182111009
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