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A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either (64)CuCl(2) or (64)CuPSMA PET/CT
SIMPLE SUMMARY: The role of PET/CT with two novel tracers was investigated in prostate cancer patients with both a biochemical failure after surgery and a presumed local failure at multiparametric MR. Overall, both PET tracers detected only about 50% of local failures. Therefore, multiparametric MR...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582802/ https://www.ncbi.nlm.nih.gov/pubmed/34771726 http://dx.doi.org/10.3390/cancers13215564 |
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author | Faiella, Adriana Sciuto, Rosa Giannarelli, Diana Bottero, Marta Farneti, Alessia Bertini, Luca Rea, Sandra Landoni, Valeria Vici, Patrizia Ferriero, Maria Consiglia Sanguineti, Giuseppe |
author_facet | Faiella, Adriana Sciuto, Rosa Giannarelli, Diana Bottero, Marta Farneti, Alessia Bertini, Luca Rea, Sandra Landoni, Valeria Vici, Patrizia Ferriero, Maria Consiglia Sanguineti, Giuseppe |
author_sort | Faiella, Adriana |
collection | PubMed |
description | SIMPLE SUMMARY: The role of PET/CT with two novel tracers was investigated in prostate cancer patients with both a biochemical failure after surgery and a presumed local failure at multiparametric MR. Overall, both PET tracers detected only about 50% of local failures. Therefore, multiparametric MR remains the exam of choice to investigate the prostatic fossa in patients who fail surgery. ABSTRACT: Background: We aimed assess the detection rate (DR) of positron emission tomography/computed tomography with two novel tracers in patients referred for salvage radiotherapy (sRT) with a presumed local recurrence at multiparametric magnetic resonance (mpMR) after radical prostatectomy (RP). Methods: The present prospective study was conducted at a single institution between August 2017 and June 2020. Eligibility criteria were undetectable PSA after RP; subsequent biochemical recurrence (two consecutive PSA rises to 0.2 ng/mL or greater); a presumed local failure at mpMR; no distant metastases at (18)F-fluorocholine PET/CT (CH/PET); no previous history of androgen deprivation therapy. Patients were offered both (64)CuCl(2) PET/CT (CU/PET) and (64)Cu-PSMA PET/CT (PSMA/PET) before sRT. After image co-registration, PET findings were compared to mpMR ones in terms of DR and independent predictors of DR investigated at logistic regression. Results: A total of 62 patients with 72 nodules at mpMR were accrued. Compared to mpMR (DR = 100%, 95%CI: 94.9–100%), DRs were 47.2% (95%CI: 36.1–58.6%) and 54.4% (95%CI: 42.7–65.7%) for CU/PET and PSMA/PET, respectively (p < 0.001 for both). Both experimental PET/CT performed particularly poorly at PSA levels consistent with early sRT. Conclusions: The two novel radiotracers are inferior to mpMR in restaging the prostatic fossa for sRT planning purposes, particularly in the context of early salvage radiotherapy. |
format | Online Article Text |
id | pubmed-8582802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85828022021-11-12 A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either (64)CuCl(2) or (64)CuPSMA PET/CT Faiella, Adriana Sciuto, Rosa Giannarelli, Diana Bottero, Marta Farneti, Alessia Bertini, Luca Rea, Sandra Landoni, Valeria Vici, Patrizia Ferriero, Maria Consiglia Sanguineti, Giuseppe Cancers (Basel) Article SIMPLE SUMMARY: The role of PET/CT with two novel tracers was investigated in prostate cancer patients with both a biochemical failure after surgery and a presumed local failure at multiparametric MR. Overall, both PET tracers detected only about 50% of local failures. Therefore, multiparametric MR remains the exam of choice to investigate the prostatic fossa in patients who fail surgery. ABSTRACT: Background: We aimed assess the detection rate (DR) of positron emission tomography/computed tomography with two novel tracers in patients referred for salvage radiotherapy (sRT) with a presumed local recurrence at multiparametric magnetic resonance (mpMR) after radical prostatectomy (RP). Methods: The present prospective study was conducted at a single institution between August 2017 and June 2020. Eligibility criteria were undetectable PSA after RP; subsequent biochemical recurrence (two consecutive PSA rises to 0.2 ng/mL or greater); a presumed local failure at mpMR; no distant metastases at (18)F-fluorocholine PET/CT (CH/PET); no previous history of androgen deprivation therapy. Patients were offered both (64)CuCl(2) PET/CT (CU/PET) and (64)Cu-PSMA PET/CT (PSMA/PET) before sRT. After image co-registration, PET findings were compared to mpMR ones in terms of DR and independent predictors of DR investigated at logistic regression. Results: A total of 62 patients with 72 nodules at mpMR were accrued. Compared to mpMR (DR = 100%, 95%CI: 94.9–100%), DRs were 47.2% (95%CI: 36.1–58.6%) and 54.4% (95%CI: 42.7–65.7%) for CU/PET and PSMA/PET, respectively (p < 0.001 for both). Both experimental PET/CT performed particularly poorly at PSA levels consistent with early sRT. Conclusions: The two novel radiotracers are inferior to mpMR in restaging the prostatic fossa for sRT planning purposes, particularly in the context of early salvage radiotherapy. MDPI 2021-11-06 /pmc/articles/PMC8582802/ /pubmed/34771726 http://dx.doi.org/10.3390/cancers13215564 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Faiella, Adriana Sciuto, Rosa Giannarelli, Diana Bottero, Marta Farneti, Alessia Bertini, Luca Rea, Sandra Landoni, Valeria Vici, Patrizia Ferriero, Maria Consiglia Sanguineti, Giuseppe A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either (64)CuCl(2) or (64)CuPSMA PET/CT |
title | A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either (64)CuCl(2) or (64)CuPSMA PET/CT |
title_full | A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either (64)CuCl(2) or (64)CuPSMA PET/CT |
title_fullStr | A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either (64)CuCl(2) or (64)CuPSMA PET/CT |
title_full_unstemmed | A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either (64)CuCl(2) or (64)CuPSMA PET/CT |
title_short | A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either (64)CuCl(2) or (64)CuPSMA PET/CT |
title_sort | prospective study assessing the post-prostatectomy detection rate of a presumed local failure at mpmr with either (64)cucl(2) or (64)cupsma pet/ct |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582802/ https://www.ncbi.nlm.nih.gov/pubmed/34771726 http://dx.doi.org/10.3390/cancers13215564 |
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