Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1
Since the discovery by Madaule and Axel in 1985 of the first Ras homologue (Rho) protein in Aplysia and its human orthologue RhoB, membership in the Rho GTPase family has grown to 20 proteins, with representatives in all eukaryotic species. These GTPases are molecular switches that cycle between act...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583009/ https://www.ncbi.nlm.nih.gov/pubmed/33126816 http://dx.doi.org/10.1080/21541248.2020.1840889 |
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author | Joo, Emily Olson, Michael F |
author_facet | Joo, Emily Olson, Michael F |
author_sort | Joo, Emily |
collection | PubMed |
description | Since the discovery by Madaule and Axel in 1985 of the first Ras homologue (Rho) protein in Aplysia and its human orthologue RhoB, membership in the Rho GTPase family has grown to 20 proteins, with representatives in all eukaryotic species. These GTPases are molecular switches that cycle between active (GTP bound) and inactivate (GDP bound) states. The exchange of GDP for GTP on Rho GTPases is facilitated by guanine exchange factors (GEFs). Approximately 80 Rho GEFs have been identified to date, and only a few GEFs associate with microtubules. The guanine nucleotide exchange factor H1, GEF-H1, is a unique GEF that associates with microtubules and is regulated by the polymerization state of microtubule networks. This review summarizes the regulation and functions of GEF-H1 and discusses the roles of GEF-H1 in human diseases. |
format | Online Article Text |
id | pubmed-8583009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-85830092021-11-12 Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1 Joo, Emily Olson, Michael F Small GTPases Review Since the discovery by Madaule and Axel in 1985 of the first Ras homologue (Rho) protein in Aplysia and its human orthologue RhoB, membership in the Rho GTPase family has grown to 20 proteins, with representatives in all eukaryotic species. These GTPases are molecular switches that cycle between active (GTP bound) and inactivate (GDP bound) states. The exchange of GDP for GTP on Rho GTPases is facilitated by guanine exchange factors (GEFs). Approximately 80 Rho GEFs have been identified to date, and only a few GEFs associate with microtubules. The guanine nucleotide exchange factor H1, GEF-H1, is a unique GEF that associates with microtubules and is regulated by the polymerization state of microtubule networks. This review summarizes the regulation and functions of GEF-H1 and discusses the roles of GEF-H1 in human diseases. Taylor & Francis 2020-10-30 /pmc/articles/PMC8583009/ /pubmed/33126816 http://dx.doi.org/10.1080/21541248.2020.1840889 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Review Joo, Emily Olson, Michael F Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1 |
title | Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1 |
title_full | Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1 |
title_fullStr | Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1 |
title_full_unstemmed | Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1 |
title_short | Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1 |
title_sort | regulation and functions of the rhoa regulatory guanine nucleotide exchange factor gef-h1 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583009/ https://www.ncbi.nlm.nih.gov/pubmed/33126816 http://dx.doi.org/10.1080/21541248.2020.1840889 |
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