Cargando…

PD-1 blockade improves the anti-tumor potency of exhausted CD3(+)CD56(+) NKT-like cells in patients with primary hepatocellular carcinoma

CD3(+)CD56(+) NKT-like cells play pivotal roles in the anti-tumor immune defense response. However, little is known regarding circulating NKT-like cells in patients with primary hepatocellular carcinoma (HCC). In the present study, we demonstrate that circulating NKT-like cells in HCC patients are f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tao, Longxiang, Wang, Shanshan, Kang, Guijie, Jiang, Shanyue, Yin, Wenwei, Zong, Lu, Li, Jing, Wang, Xuefu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583083/ https://www.ncbi.nlm.nih.gov/pubmed/34777920 http://dx.doi.org/10.1080/2162402X.2021.2002068

Ejemplares similares

The Function of CD3(+)CD56(+) NKT-Like Cells in HIV-Infected Individuals
por: Jiang, Yongjun, et al.
Publicado: (2014)

Dysfunction of circulating CD3(+)CD56(+) NKT-like cells in type 2 diabetes mellitus
por: Tang, Ling, et al.
Publicado: (2023)

Can we define CD3(+)CD56(+) cells as NKT cells with impunity?
por: Lenart, Marzena, et al.
Publicado: (2021)

Altered phenotypic and functional characteristics of CD3(+)CD56(+) NKT-like cells in human gastric cancer
por: Peng, Liu-sheng, et al.
Publicado: (2016)

Contribution of Leishmania braziliensis antigen-specific CD4(+) T, CD8(+) T, NK and CD3(+)CD56(+)NKT cells in the immunopathogenesis of cutaneous leishmaniasis patients: Cytotoxic, activation and exhaustion profiles
por: Cunha, Clarissa F., et al.
Publicado: (2020)

Baseline CD3+CD56+ (NKT-like) Cells and the Outcome of Influenza Vaccination in Children Undergoing Chemotherapy
por: Leibinger, Evelin A., et al.
Publicado: (2021)

Trained Immunity of IL-12-, IL-15-, and IL-18-Induced CD(3)+CD(56)+ NKT-Like Cells
por: Zhu, Siyu, et al.
Publicado: (2022)

NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors
por: Almeida, Jani-Sofia, et al.
Publicado: (2019)

PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1(hi)CD39(+) CD4 T cells
por: Balança, Camille-Charlotte, et al.
Publicado: (2021)

NK cells CD56(bright) and CD56(dim) subset cytokine loss and exhaustion is associated with impaired survival in myeloma
por: Seymour, Frances, et al.
Publicado: (2022)

CD3(+)/CD56(+) NKT-like Cells Show Imbalanced Control Immediately after Exercise in Delayed-Onset Muscle Soreness
por: Sonkodi, Balázs, et al.
Publicado: (2022)

Altered phenotypic and metabolic characteristics of FOXP3(+)CD3(+)CD56(+) natural killer T (NKT)-like cells in human malignant pleural effusion
por: Wang, Zi-Hao, et al.
Publicado: (2022)

Peripheral PD-1+CD56+ T-cell frequencies correlate with outcome in stage IV melanoma under PD-1 blockade
por: Bochem, Jonas, et al.
Publicado: (2019)

The frequencies of peripheral blood CD5(+)CD19(+) B cells, CD3(−)CD16(+)CD56(+) NK, and CD3(+)CD56(+) NKT cells and serum interleukin-10 in patients with multiple sclerosis and neuromyelitis optica spectrum disorder
por: Khani, Leila, et al.
Publicado: (2022)

Circulating Exhausted PD-1(+)CD39(+) Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade
por: Martinez-Gomez, Carlos, et al.
Publicado: (2022)

Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors
por: Khan, Saad M, et al.
Publicado: (2022)

NKT-like (CD3 + CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing
por: Kaszubowska, Lucyna, et al.
Publicado: (2022)

Correction: Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors
Publicado: (2023)

Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8(+) exhausted-like T cells
por: Li, Siqi, et al.
Publicado: (2023)

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
por: Nakamoto, Nobuhiro, et al.
Publicado: (2009)

Combination Therapy with iRGD-antiCD3 and PD-1 Blockade Enhances Antitumor Potency of Cord Blood-Derived T Cells
por: Zhu, Mei, et al.
Publicado: (2021)

Functional Exhaustion of HBV-Specific CD8 T Cells Impedes PD-L1 Blockade Efficacy in Chronic HBV Infection
por: Ferrando-Martinez, Sara, et al.
Publicado: (2021)

Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8(+) T-cell activation and exhaustion
por: Belizário, José, et al.
Publicado: (2020)

Reversal of the CD8(+) T-Cell Exhaustion Induced by Chronic HIV-1 Infection Through Combined Blockade of the Adenosine and PD-1 Pathways
por: Li, Jing, et al.
Publicado: (2021)

Pollution of mycological surfaces in hospital emergency departments correlates positively with blood NKT CD3(+) 16(+) 56(+) and negatively with CD4(+) cell levels of their staff
por: Suska, Milena, et al.
Publicado: (2016)

Alterations in the CD56(−) and CD56(+) T Cell Subsets during COVID-19
por: Vavilova, Julia D., et al.
Publicado: (2023)

PD1(Hi) CD8(+) T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma
por: Ma, Jiaqiang, et al.
Publicado: (2019)

CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2013)

PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127(+) and KLRG1(+) CD8 T cells
por: Hui, Zhenzhen, et al.
Publicado: (2023)

CD38 marks the exhausted CD8(+) tissue-resident memory T cells in hepatocellular carcinoma
por: Reolo, Marie J. Y., et al.
Publicado: (2023)

CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells
por: Zhang, Yuhan, et al.
Publicado: (2023)

PD‐1/PD‐L1 blockade rescue exhausted CD8+ T cells in gastrointestinal stromal tumours via the PI3K/Akt/mTOR signalling pathway
por: Zhao, Rui, et al.
Publicado: (2019)

Correction: CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2016)

Correction: CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2017)

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
por: Banchereau, Romain, et al.
Publicado: (2021)

High Frequencies of Phenotypically and Functionally Senescent and Exhausted CD56(+)CD57(+)PD-1(+) Natural Killer Cells, SARS-CoV-2-Specific Memory CD4(+) and CD8(+) T cells Associated with Severe Disease in Unvaccinated COVID-19 Patients
por: Srivastava, Ruchi, et al.
Publicado: (2022)

Systemic CD4 Immunity and PD-L1/PD-1 Blockade Immunotherapy
por: Escors, David, et al.
Publicado: (2022)

STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia
por: Klein, Klara, et al.
Publicado: (2019)

EBV Promotes Human CD8(+) NKT Cell Development
por: Yuling, He, et al.
Publicado: (2010)

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade
por: Freeman, Gordon J., et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_nkl7jhe3355d58kkggg16d1uog