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Emerging roles for Rho GTPases operating at the Golgi complex

Rho GTPases are known to play an essential role in fundamental processes such as defining cell shape, polarity and migration. As such, the majority of Rho GTPases localize and function at, or close to, the plasma membrane. However, it is becoming increasingly clear that a number of Rho family protei...

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Autores principales: Mysior, Margaritha M., Simpson, Jeremy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583101/
https://www.ncbi.nlm.nih.gov/pubmed/32881632
http://dx.doi.org/10.1080/21541248.2020.1812873
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author Mysior, Margaritha M.
Simpson, Jeremy C.
author_facet Mysior, Margaritha M.
Simpson, Jeremy C.
author_sort Mysior, Margaritha M.
collection PubMed
description Rho GTPases are known to play an essential role in fundamental processes such as defining cell shape, polarity and migration. As such, the majority of Rho GTPases localize and function at, or close to, the plasma membrane. However, it is becoming increasingly clear that a number of Rho family proteins are also associated with the Golgi complex, where they not only regulate events at this organelle but also more widely across the cell. Given the central location of this organelle, and the numerous membrane trafficking pathways that connect it to both the endocytic and secretory systems of cells, it is clear that the Golgi is fundamental for maintaining cellular homoeostasis. In this review, we describe these GTPases in the context of how they regulate Golgi architecture, membrane trafficking into and away from this organelle, and cell polarity and migration. We summarize the key findings that show the growing importance of the pool of Rho GTPases associated with Golgi function, namely Cdc42, RhoA, RhoD, RhoBTB1 and RhoBTB3, and we discuss how they act in concert with other key families of molecules associated with the Golgi, including Rab GTPases and matrix proteins.
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spelling pubmed-85831012021-11-12 Emerging roles for Rho GTPases operating at the Golgi complex Mysior, Margaritha M. Simpson, Jeremy C. Small GTPases Review Rho GTPases are known to play an essential role in fundamental processes such as defining cell shape, polarity and migration. As such, the majority of Rho GTPases localize and function at, or close to, the plasma membrane. However, it is becoming increasingly clear that a number of Rho family proteins are also associated with the Golgi complex, where they not only regulate events at this organelle but also more widely across the cell. Given the central location of this organelle, and the numerous membrane trafficking pathways that connect it to both the endocytic and secretory systems of cells, it is clear that the Golgi is fundamental for maintaining cellular homoeostasis. In this review, we describe these GTPases in the context of how they regulate Golgi architecture, membrane trafficking into and away from this organelle, and cell polarity and migration. We summarize the key findings that show the growing importance of the pool of Rho GTPases associated with Golgi function, namely Cdc42, RhoA, RhoD, RhoBTB1 and RhoBTB3, and we discuss how they act in concert with other key families of molecules associated with the Golgi, including Rab GTPases and matrix proteins. Taylor & Francis 2020-09-03 /pmc/articles/PMC8583101/ /pubmed/32881632 http://dx.doi.org/10.1080/21541248.2020.1812873 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Mysior, Margaritha M.
Simpson, Jeremy C.
Emerging roles for Rho GTPases operating at the Golgi complex
title Emerging roles for Rho GTPases operating at the Golgi complex
title_full Emerging roles for Rho GTPases operating at the Golgi complex
title_fullStr Emerging roles for Rho GTPases operating at the Golgi complex
title_full_unstemmed Emerging roles for Rho GTPases operating at the Golgi complex
title_short Emerging roles for Rho GTPases operating at the Golgi complex
title_sort emerging roles for rho gtpases operating at the golgi complex
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583101/
https://www.ncbi.nlm.nih.gov/pubmed/32881632
http://dx.doi.org/10.1080/21541248.2020.1812873
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