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Prostate Cancer Survival by Risk and Other Prognostic Factors in Mallorca, Spain

Studies about the survival of patients with prostate cancer by stage or risk of progression are scarce. The aims of this study were (1) to determine the cause-specific survival by risk in prostate cancer patients in Mallorca diagnosed in the period 2006–2011; (2) to identify the factors that explain...

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Autores principales: Montaño, Juan José, Barceló, Antoni, Franch, Paula, Galceran, Jaume, Ameijide, Alberto, Pons, Jaime, Ramos, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583124/
https://www.ncbi.nlm.nih.gov/pubmed/34769675
http://dx.doi.org/10.3390/ijerph182111156
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author Montaño, Juan José
Barceló, Antoni
Franch, Paula
Galceran, Jaume
Ameijide, Alberto
Pons, Jaime
Ramos, Maria
author_facet Montaño, Juan José
Barceló, Antoni
Franch, Paula
Galceran, Jaume
Ameijide, Alberto
Pons, Jaime
Ramos, Maria
author_sort Montaño, Juan José
collection PubMed
description Studies about the survival of patients with prostate cancer by stage or risk of progression are scarce. The aims of this study were (1) to determine the cause-specific survival by risk in prostate cancer patients in Mallorca diagnosed in the period 2006–2011; (2) to identify the factors that explain and predict the likelihood of survival and the risk of dying from this type of cancer; and (3) to determine the distribution of prostate cancer by risk in the patients in Mallorca diagnosed in the period 2006–2011. Incident prostate cancer cases diagnosed between 2006 and 2011 were identified through the Mallorca Cancer Registry. We collected age; date and method of diagnosis; date of follow-up or death; T, N, M and stage according to the TNM 7th edition; Gleason score; prostate-specific antigen (PSA); histology according to the International Classification of Diseases for Oncology (ICD-O) 3rd edition, comorbidities and treatments. We calculated risk in four categories: low, medium, high and very high. The end point of follow-up was 31 December 2014. Multiple imputation (MI) was performed to estimate cases with unknown risk. We identified 2921 cases. Five years after diagnosis, survival after MI was 89% globally, and was 100% for low-risk cases, 96% for medium risk, 93% for high risk and 69% for very-high-risk cases. Cases with histology other than adenocarcinoma, with high (and especially very high) risk, as well as with systemic, mixed and observation/unspecified treatments had worse prognoses.
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spelling pubmed-85831242021-11-12 Prostate Cancer Survival by Risk and Other Prognostic Factors in Mallorca, Spain Montaño, Juan José Barceló, Antoni Franch, Paula Galceran, Jaume Ameijide, Alberto Pons, Jaime Ramos, Maria Int J Environ Res Public Health Article Studies about the survival of patients with prostate cancer by stage or risk of progression are scarce. The aims of this study were (1) to determine the cause-specific survival by risk in prostate cancer patients in Mallorca diagnosed in the period 2006–2011; (2) to identify the factors that explain and predict the likelihood of survival and the risk of dying from this type of cancer; and (3) to determine the distribution of prostate cancer by risk in the patients in Mallorca diagnosed in the period 2006–2011. Incident prostate cancer cases diagnosed between 2006 and 2011 were identified through the Mallorca Cancer Registry. We collected age; date and method of diagnosis; date of follow-up or death; T, N, M and stage according to the TNM 7th edition; Gleason score; prostate-specific antigen (PSA); histology according to the International Classification of Diseases for Oncology (ICD-O) 3rd edition, comorbidities and treatments. We calculated risk in four categories: low, medium, high and very high. The end point of follow-up was 31 December 2014. Multiple imputation (MI) was performed to estimate cases with unknown risk. We identified 2921 cases. Five years after diagnosis, survival after MI was 89% globally, and was 100% for low-risk cases, 96% for medium risk, 93% for high risk and 69% for very-high-risk cases. Cases with histology other than adenocarcinoma, with high (and especially very high) risk, as well as with systemic, mixed and observation/unspecified treatments had worse prognoses. MDPI 2021-10-24 /pmc/articles/PMC8583124/ /pubmed/34769675 http://dx.doi.org/10.3390/ijerph182111156 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Montaño, Juan José
Barceló, Antoni
Franch, Paula
Galceran, Jaume
Ameijide, Alberto
Pons, Jaime
Ramos, Maria
Prostate Cancer Survival by Risk and Other Prognostic Factors in Mallorca, Spain
title Prostate Cancer Survival by Risk and Other Prognostic Factors in Mallorca, Spain
title_full Prostate Cancer Survival by Risk and Other Prognostic Factors in Mallorca, Spain
title_fullStr Prostate Cancer Survival by Risk and Other Prognostic Factors in Mallorca, Spain
title_full_unstemmed Prostate Cancer Survival by Risk and Other Prognostic Factors in Mallorca, Spain
title_short Prostate Cancer Survival by Risk and Other Prognostic Factors in Mallorca, Spain
title_sort prostate cancer survival by risk and other prognostic factors in mallorca, spain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583124/
https://www.ncbi.nlm.nih.gov/pubmed/34769675
http://dx.doi.org/10.3390/ijerph182111156
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