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Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused
Even several months after the start of a massive vaccination campaign against COVID-19, mortality and hospital admission are still high in many countries. Monoclonal antibodies against SARS-CoV-2 are the ideal complement to vaccination in infected subjects who are at high risk for progression to sev...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583134/ https://www.ncbi.nlm.nih.gov/pubmed/34769678 http://dx.doi.org/10.3390/ijerph182111159 |
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author | Gentile, Ivan Maraolo, Alberto Enrico Buonomo, Antonio Riccardo Nobile, Mariano Piscitelli, Prisco Miani, Alessandro Schiano Moriello, Nicola |
author_facet | Gentile, Ivan Maraolo, Alberto Enrico Buonomo, Antonio Riccardo Nobile, Mariano Piscitelli, Prisco Miani, Alessandro Schiano Moriello, Nicola |
author_sort | Gentile, Ivan |
collection | PubMed |
description | Even several months after the start of a massive vaccination campaign against COVID-19, mortality and hospital admission are still high in many countries. Monoclonal antibodies against SARS-CoV-2 are the ideal complement to vaccination in infected subjects who are at high risk for progression to severe disease. Based on data of the Italian Ministry of Health, in the period April–August 2021, monoclonal antibodies were prescribed to 6322 patients. In the same period, 70,022 patients over 70 years old became infected with SARS-CoV-2. Even considering that all monoclonal antibodies were prescribed to this category of patients, we calculated that only 9% of these subjects received the treatment. Moreover, using efficacy data provided by clinal trials, we estimated the potential benefit in terms of reduction of hospital admissions and deaths. Considering utilisation of monoclonal antibodies in half infected patients over 70 years, we estimated that hospital admissions and deaths might have been reduced by 7666 and 3507, respectively. Finally, we calculated the economic benefit of monoclonal use. In the same scenario (50% use of monoclonal antibodies to patients over 70), we estimated potential savings of USD 117,410,105. In conclusion, monoclonal antibodies were used in a small proportion of patients over 70 in Italy. A more extensive use might have resulted in a marked decrease in hospital admissions, deaths and in conspicuous saving for the health system. |
format | Online Article Text |
id | pubmed-8583134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85831342021-11-12 Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused Gentile, Ivan Maraolo, Alberto Enrico Buonomo, Antonio Riccardo Nobile, Mariano Piscitelli, Prisco Miani, Alessandro Schiano Moriello, Nicola Int J Environ Res Public Health Brief Report Even several months after the start of a massive vaccination campaign against COVID-19, mortality and hospital admission are still high in many countries. Monoclonal antibodies against SARS-CoV-2 are the ideal complement to vaccination in infected subjects who are at high risk for progression to severe disease. Based on data of the Italian Ministry of Health, in the period April–August 2021, monoclonal antibodies were prescribed to 6322 patients. In the same period, 70,022 patients over 70 years old became infected with SARS-CoV-2. Even considering that all monoclonal antibodies were prescribed to this category of patients, we calculated that only 9% of these subjects received the treatment. Moreover, using efficacy data provided by clinal trials, we estimated the potential benefit in terms of reduction of hospital admissions and deaths. Considering utilisation of monoclonal antibodies in half infected patients over 70 years, we estimated that hospital admissions and deaths might have been reduced by 7666 and 3507, respectively. Finally, we calculated the economic benefit of monoclonal use. In the same scenario (50% use of monoclonal antibodies to patients over 70), we estimated potential savings of USD 117,410,105. In conclusion, monoclonal antibodies were used in a small proportion of patients over 70 in Italy. A more extensive use might have resulted in a marked decrease in hospital admissions, deaths and in conspicuous saving for the health system. MDPI 2021-10-24 /pmc/articles/PMC8583134/ /pubmed/34769678 http://dx.doi.org/10.3390/ijerph182111159 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Gentile, Ivan Maraolo, Alberto Enrico Buonomo, Antonio Riccardo Nobile, Mariano Piscitelli, Prisco Miani, Alessandro Schiano Moriello, Nicola Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused |
title | Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused |
title_full | Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused |
title_fullStr | Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused |
title_full_unstemmed | Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused |
title_short | Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused |
title_sort | monoclonal antibodies against sars-cov-2: potential game-changer still underused |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583134/ https://www.ncbi.nlm.nih.gov/pubmed/34769678 http://dx.doi.org/10.3390/ijerph182111159 |
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