Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy

Pathological changes involving TDP-43 protein (‘TDP-43 proteinopathy’) are typical for several neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD). FTLD-TDP cases are characterized by increased binding of TDP-43 to an abundant lncRNA, NEAT1, in the cortex. However it is un...

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Detalles Bibliográficos
Autores principales: Matsukawa, Koji, Kukharsky, Michail S., Park, Sei-Kyoung, Park, Sangeun, Watanabe, Naruaki, Iwatsubo, Takeshi, Hashimoto, Tadafumi, Liebman, Susan W., Shelkovnikova, Tatyana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583295/
https://www.ncbi.nlm.nih.gov/pubmed/33427561
http://dx.doi.org/10.1080/15476286.2020.1860580

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