Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma

SIMPLE SUMMARY: This study reported, for the first time, on the expression and activity of the dipeptidyl peptidase 4 (DPP4) family during the development of hepatocellular carcinoma (HCC). We also demonstrated that the pan-DPP inhibitory compound ARI-4175 significantly reduced the number of macrosc...

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Detalles Bibliográficos
Autores principales: Henderson, James M., Xiang, Michelle S. W., Huang, Jiali Carrie, Wetzel, Stefanie, Jiang, Linxuan, Lai, Jack H., Wu, Wengen, Kench, James G., Bachovchin, William W., Roediger, Ben, McCaughan, Geoffrey W., Zhang, Hui Emma, Gorrell, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583374/
https://www.ncbi.nlm.nih.gov/pubmed/34771657
http://dx.doi.org/10.3390/cancers13215495

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