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Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens

The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such a...

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Autores principales: Arafune, Johichi, Tsujiguchi, Hiromasa, Hara, Akinori, Shimizu, Yukari, Hori, Daisuke, Nguyen, Thao Thi Thu, Suzuki, Fumihiko, Hamagishi, Toshio, Yamada, Yohei, Nakamura, Haruki, Yoshikawa, Takahiro, Hayashi, Koichiro, Shibata, Aki, Fukutomi, Yuma, Ohya, Yukihiro, Yamamoto-Hanada, Kiwako, Muto, Go, Hirota, Ryoji, Konoshita, Tadashi, Kambayashi, Yasuhiro, Nakamura, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583381/
https://www.ncbi.nlm.nih.gov/pubmed/34770171
http://dx.doi.org/10.3390/ijerph182111657
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author Arafune, Johichi
Tsujiguchi, Hiromasa
Hara, Akinori
Shimizu, Yukari
Hori, Daisuke
Nguyen, Thao Thi Thu
Suzuki, Fumihiko
Hamagishi, Toshio
Yamada, Yohei
Nakamura, Haruki
Yoshikawa, Takahiro
Hayashi, Koichiro
Shibata, Aki
Fukutomi, Yuma
Ohya, Yukihiro
Yamamoto-Hanada, Kiwako
Muto, Go
Hirota, Ryoji
Konoshita, Tadashi
Kambayashi, Yasuhiro
Nakamura, Hiroyuki
author_facet Arafune, Johichi
Tsujiguchi, Hiromasa
Hara, Akinori
Shimizu, Yukari
Hori, Daisuke
Nguyen, Thao Thi Thu
Suzuki, Fumihiko
Hamagishi, Toshio
Yamada, Yohei
Nakamura, Haruki
Yoshikawa, Takahiro
Hayashi, Koichiro
Shibata, Aki
Fukutomi, Yuma
Ohya, Yukihiro
Yamamoto-Hanada, Kiwako
Muto, Go
Hirota, Ryoji
Konoshita, Tadashi
Kambayashi, Yasuhiro
Nakamura, Hiroyuki
author_sort Arafune, Johichi
collection PubMed
description The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such as parabens (CAS number, 94-13-3). It currently remains unclear whether parabens, which are included in many daily consumer products such as cosmetics, shampoos, and personal care products as preservative antimicrobial agents, induce or aggravate allergies. Therefore, the aim of the present study was to examine the relationship between exposure to parabens and the prevalence of allergic diseases in Japanese children. The cross-sectional epidemiology of 236 children aged 0–3 years who underwent health examinations in Shika town in Japan assessed individual exposure to parabens using urinary concentrations of parabens. The results obtained showed that the prevalence of atopic dermatitis was significantly higher in children with high urinary concentrations of parabens than in those with low concentrations (p < 0.001). This relationship remained significant after adjustments for confounding factors, such as age, sex, Kaup’s index, and passive smoking (p < 0.001). In conclusion, the present results from a population study suggested a relationship between atopic dermatitis and exposure to parabens. A longitudinal study using a larger sample number and a detailed examination of atopic dermatitis, including EASI scores and exposure to parabens, will be necessary.
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spelling pubmed-85833812021-11-12 Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens Arafune, Johichi Tsujiguchi, Hiromasa Hara, Akinori Shimizu, Yukari Hori, Daisuke Nguyen, Thao Thi Thu Suzuki, Fumihiko Hamagishi, Toshio Yamada, Yohei Nakamura, Haruki Yoshikawa, Takahiro Hayashi, Koichiro Shibata, Aki Fukutomi, Yuma Ohya, Yukihiro Yamamoto-Hanada, Kiwako Muto, Go Hirota, Ryoji Konoshita, Tadashi Kambayashi, Yasuhiro Nakamura, Hiroyuki Int J Environ Res Public Health Article The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such as parabens (CAS number, 94-13-3). It currently remains unclear whether parabens, which are included in many daily consumer products such as cosmetics, shampoos, and personal care products as preservative antimicrobial agents, induce or aggravate allergies. Therefore, the aim of the present study was to examine the relationship between exposure to parabens and the prevalence of allergic diseases in Japanese children. The cross-sectional epidemiology of 236 children aged 0–3 years who underwent health examinations in Shika town in Japan assessed individual exposure to parabens using urinary concentrations of parabens. The results obtained showed that the prevalence of atopic dermatitis was significantly higher in children with high urinary concentrations of parabens than in those with low concentrations (p < 0.001). This relationship remained significant after adjustments for confounding factors, such as age, sex, Kaup’s index, and passive smoking (p < 0.001). In conclusion, the present results from a population study suggested a relationship between atopic dermatitis and exposure to parabens. A longitudinal study using a larger sample number and a detailed examination of atopic dermatitis, including EASI scores and exposure to parabens, will be necessary. MDPI 2021-11-06 /pmc/articles/PMC8583381/ /pubmed/34770171 http://dx.doi.org/10.3390/ijerph182111657 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arafune, Johichi
Tsujiguchi, Hiromasa
Hara, Akinori
Shimizu, Yukari
Hori, Daisuke
Nguyen, Thao Thi Thu
Suzuki, Fumihiko
Hamagishi, Toshio
Yamada, Yohei
Nakamura, Haruki
Yoshikawa, Takahiro
Hayashi, Koichiro
Shibata, Aki
Fukutomi, Yuma
Ohya, Yukihiro
Yamamoto-Hanada, Kiwako
Muto, Go
Hirota, Ryoji
Konoshita, Tadashi
Kambayashi, Yasuhiro
Nakamura, Hiroyuki
Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens
title Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens
title_full Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens
title_fullStr Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens
title_full_unstemmed Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens
title_short Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens
title_sort increased prevalence of atopic dermatitis in children aged 0–3 years highly exposed to parabens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583381/
https://www.ncbi.nlm.nih.gov/pubmed/34770171
http://dx.doi.org/10.3390/ijerph182111657
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