Cargando…
Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens
The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583381/ https://www.ncbi.nlm.nih.gov/pubmed/34770171 http://dx.doi.org/10.3390/ijerph182111657 |
_version_ | 1784597190828621824 |
---|---|
author | Arafune, Johichi Tsujiguchi, Hiromasa Hara, Akinori Shimizu, Yukari Hori, Daisuke Nguyen, Thao Thi Thu Suzuki, Fumihiko Hamagishi, Toshio Yamada, Yohei Nakamura, Haruki Yoshikawa, Takahiro Hayashi, Koichiro Shibata, Aki Fukutomi, Yuma Ohya, Yukihiro Yamamoto-Hanada, Kiwako Muto, Go Hirota, Ryoji Konoshita, Tadashi Kambayashi, Yasuhiro Nakamura, Hiroyuki |
author_facet | Arafune, Johichi Tsujiguchi, Hiromasa Hara, Akinori Shimizu, Yukari Hori, Daisuke Nguyen, Thao Thi Thu Suzuki, Fumihiko Hamagishi, Toshio Yamada, Yohei Nakamura, Haruki Yoshikawa, Takahiro Hayashi, Koichiro Shibata, Aki Fukutomi, Yuma Ohya, Yukihiro Yamamoto-Hanada, Kiwako Muto, Go Hirota, Ryoji Konoshita, Tadashi Kambayashi, Yasuhiro Nakamura, Hiroyuki |
author_sort | Arafune, Johichi |
collection | PubMed |
description | The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such as parabens (CAS number, 94-13-3). It currently remains unclear whether parabens, which are included in many daily consumer products such as cosmetics, shampoos, and personal care products as preservative antimicrobial agents, induce or aggravate allergies. Therefore, the aim of the present study was to examine the relationship between exposure to parabens and the prevalence of allergic diseases in Japanese children. The cross-sectional epidemiology of 236 children aged 0–3 years who underwent health examinations in Shika town in Japan assessed individual exposure to parabens using urinary concentrations of parabens. The results obtained showed that the prevalence of atopic dermatitis was significantly higher in children with high urinary concentrations of parabens than in those with low concentrations (p < 0.001). This relationship remained significant after adjustments for confounding factors, such as age, sex, Kaup’s index, and passive smoking (p < 0.001). In conclusion, the present results from a population study suggested a relationship between atopic dermatitis and exposure to parabens. A longitudinal study using a larger sample number and a detailed examination of atopic dermatitis, including EASI scores and exposure to parabens, will be necessary. |
format | Online Article Text |
id | pubmed-8583381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85833812021-11-12 Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens Arafune, Johichi Tsujiguchi, Hiromasa Hara, Akinori Shimizu, Yukari Hori, Daisuke Nguyen, Thao Thi Thu Suzuki, Fumihiko Hamagishi, Toshio Yamada, Yohei Nakamura, Haruki Yoshikawa, Takahiro Hayashi, Koichiro Shibata, Aki Fukutomi, Yuma Ohya, Yukihiro Yamamoto-Hanada, Kiwako Muto, Go Hirota, Ryoji Konoshita, Tadashi Kambayashi, Yasuhiro Nakamura, Hiroyuki Int J Environ Res Public Health Article The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such as parabens (CAS number, 94-13-3). It currently remains unclear whether parabens, which are included in many daily consumer products such as cosmetics, shampoos, and personal care products as preservative antimicrobial agents, induce or aggravate allergies. Therefore, the aim of the present study was to examine the relationship between exposure to parabens and the prevalence of allergic diseases in Japanese children. The cross-sectional epidemiology of 236 children aged 0–3 years who underwent health examinations in Shika town in Japan assessed individual exposure to parabens using urinary concentrations of parabens. The results obtained showed that the prevalence of atopic dermatitis was significantly higher in children with high urinary concentrations of parabens than in those with low concentrations (p < 0.001). This relationship remained significant after adjustments for confounding factors, such as age, sex, Kaup’s index, and passive smoking (p < 0.001). In conclusion, the present results from a population study suggested a relationship between atopic dermatitis and exposure to parabens. A longitudinal study using a larger sample number and a detailed examination of atopic dermatitis, including EASI scores and exposure to parabens, will be necessary. MDPI 2021-11-06 /pmc/articles/PMC8583381/ /pubmed/34770171 http://dx.doi.org/10.3390/ijerph182111657 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Arafune, Johichi Tsujiguchi, Hiromasa Hara, Akinori Shimizu, Yukari Hori, Daisuke Nguyen, Thao Thi Thu Suzuki, Fumihiko Hamagishi, Toshio Yamada, Yohei Nakamura, Haruki Yoshikawa, Takahiro Hayashi, Koichiro Shibata, Aki Fukutomi, Yuma Ohya, Yukihiro Yamamoto-Hanada, Kiwako Muto, Go Hirota, Ryoji Konoshita, Tadashi Kambayashi, Yasuhiro Nakamura, Hiroyuki Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens |
title | Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens |
title_full | Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens |
title_fullStr | Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens |
title_full_unstemmed | Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens |
title_short | Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens |
title_sort | increased prevalence of atopic dermatitis in children aged 0–3 years highly exposed to parabens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583381/ https://www.ncbi.nlm.nih.gov/pubmed/34770171 http://dx.doi.org/10.3390/ijerph182111657 |
work_keys_str_mv | AT arafunejohichi increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT tsujiguchihiromasa increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT haraakinori increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT shimizuyukari increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT horidaisuke increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT nguyenthaothithu increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT suzukifumihiko increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT hamagishitoshio increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT yamadayohei increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT nakamuraharuki increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT yoshikawatakahiro increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT hayashikoichiro increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT shibataaki increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT fukutomiyuma increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT ohyayukihiro increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT yamamotohanadakiwako increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT mutogo increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT hirotaryoji increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT konoshitatadashi increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT kambayashiyasuhiro increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens AT nakamurahiroyuki increasedprevalenceofatopicdermatitisinchildrenaged03yearshighlyexposedtoparabens |