Cargando…

Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma

Meningioma (MGM) is the most common type of intracranial tumor in adults. The validation of novel prognostic biomarkers to better inform tumor stratification and clinical prognosis is urgently needed. Many molecular and cellular alterations have been described in MGM tumors over the past few years,...

Descripción completa

Detalles Bibliográficos
Autores principales: Roesler, Rafael, Souza, Barbara Kunzler, Isolan, Gustavo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583503/
https://www.ncbi.nlm.nih.gov/pubmed/34768783
http://dx.doi.org/10.3390/ijms222111352
_version_ 1784597219943383040
author Roesler, Rafael
Souza, Barbara Kunzler
Isolan, Gustavo R.
author_facet Roesler, Rafael
Souza, Barbara Kunzler
Isolan, Gustavo R.
author_sort Roesler, Rafael
collection PubMed
description Meningioma (MGM) is the most common type of intracranial tumor in adults. The validation of novel prognostic biomarkers to better inform tumor stratification and clinical prognosis is urgently needed. Many molecular and cellular alterations have been described in MGM tumors over the past few years, providing a rational basis for the identification of biomarkers and therapeutic targets. The role of receptor tyrosine kinases (RTKs) as oncogenes, including those of the ErbB family of receptors, has been well established in several cancer types. Here, we review histological, molecular, and clinical evidence suggesting that RTKs, including the epidermal growth factor receptor (EGFR, ErbB1), as well as other members of the ErbB family, may be useful as biomarkers and therapeutic targets in MGM.
format Online
Article
Text
id pubmed-8583503
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85835032021-11-12 Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma Roesler, Rafael Souza, Barbara Kunzler Isolan, Gustavo R. Int J Mol Sci Review Meningioma (MGM) is the most common type of intracranial tumor in adults. The validation of novel prognostic biomarkers to better inform tumor stratification and clinical prognosis is urgently needed. Many molecular and cellular alterations have been described in MGM tumors over the past few years, providing a rational basis for the identification of biomarkers and therapeutic targets. The role of receptor tyrosine kinases (RTKs) as oncogenes, including those of the ErbB family of receptors, has been well established in several cancer types. Here, we review histological, molecular, and clinical evidence suggesting that RTKs, including the epidermal growth factor receptor (EGFR, ErbB1), as well as other members of the ErbB family, may be useful as biomarkers and therapeutic targets in MGM. MDPI 2021-10-21 /pmc/articles/PMC8583503/ /pubmed/34768783 http://dx.doi.org/10.3390/ijms222111352 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Roesler, Rafael
Souza, Barbara Kunzler
Isolan, Gustavo R.
Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma
title Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma
title_full Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma
title_fullStr Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma
title_full_unstemmed Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma
title_short Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers and Therapeutic Targets in Meningioma
title_sort receptor tyrosine kinases as candidate prognostic biomarkers and therapeutic targets in meningioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583503/
https://www.ncbi.nlm.nih.gov/pubmed/34768783
http://dx.doi.org/10.3390/ijms222111352
work_keys_str_mv AT roeslerrafael receptortyrosinekinasesascandidateprognosticbiomarkersandtherapeutictargetsinmeningioma
AT souzabarbarakunzler receptortyrosinekinasesascandidateprognosticbiomarkersandtherapeutictargetsinmeningioma
AT isolangustavor receptortyrosinekinasesascandidateprognosticbiomarkersandtherapeutictargetsinmeningioma