A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma

SIMPLE SUMMARY: Uveal melanoma is a rare subset of melanoma characterized by the presence of early initiating GNAQ/11 mutations, with downstream activation of several pathways which are thought to contribute to cell growth. Based on clinical and preclinical data supporting targeting of protein kinas...

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Detalles Bibliográficos
Autores principales: Shoushtari, Alexander N., Khan, Shaheer, Komatsubara, Kimberly, Feun, Lynn, Acquavella, Nicolas, Singh-Kandah, Shahnaz, Negri, Tiffany, Nesson, Alexandra, Abbate, Kelly, Cremers, Serge, Musi, Elgilda, Ambrosini, Grazia, Lee, Shing, Schwartz, Gary K., Carvajal, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583628/
https://www.ncbi.nlm.nih.gov/pubmed/34771668
http://dx.doi.org/10.3390/cancers13215504

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