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p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR dipeptide repeats, which are encoded by the chromosome 9 open reading frame 72 (C9orf72) gene. Recently, it was shown that poly-PR/GR alters chromatin accessibility, w...

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Detalles Bibliográficos
Autores principales:	Usluer, Sinem, Spreitzer, Emil, Bourgeois, Benjamin, Madl, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583712/ https://www.ncbi.nlm.nih.gov/pubmed/34768862 http://dx.doi.org/10.3390/ijms222111431

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