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Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study

Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present...

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Autores principales: Fu, Ruisen, Feng, Yili, Bertrand, David, Du, Tianming, Liu, Youjun, Willie, Bettina M., Yang, Haisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583714/
https://www.ncbi.nlm.nih.gov/pubmed/34769163
http://dx.doi.org/10.3390/ijms222111734
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author Fu, Ruisen
Feng, Yili
Bertrand, David
Du, Tianming
Liu, Youjun
Willie, Bettina M.
Yang, Haisheng
author_facet Fu, Ruisen
Feng, Yili
Bertrand, David
Du, Tianming
Liu, Youjun
Willie, Bettina M.
Yang, Haisheng
author_sort Fu, Ruisen
collection PubMed
description Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present study, a distraction strategy with varying distraction rates (i.e., “rate-varying distraction”) is proposed, with the aim of shortening the distraction time and improving the efficiency of DO. We hypothesized that faster and better healing can be achieved with rate-varying distractions, as compared with constant-rate distractions. A computational model incorporating the viscoelastic behaviors of the callus tissues and the mechano-regulatory tissue differentiation laws was developed and validated to predict the bone regeneration process during DO. The effect of rate-varying distraction on the healing outcomes (bony bridging time and bone formation) was examined. Compared to the constant low-rate distraction, a low-to-high rate-varying distraction provided a favorable mechanical environment for angiogenesis and bone tissue differentiation, throughout the distraction and consolidation phase, leading to an improved healing outcome with a shortened healing time. These results suggest that a rate-varying clinical strategy could reduce the overall treatment time of DO and decrease the risk of complications related to the external fixator.
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spelling pubmed-85837142021-11-12 Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study Fu, Ruisen Feng, Yili Bertrand, David Du, Tianming Liu, Youjun Willie, Bettina M. Yang, Haisheng Int J Mol Sci Article Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present study, a distraction strategy with varying distraction rates (i.e., “rate-varying distraction”) is proposed, with the aim of shortening the distraction time and improving the efficiency of DO. We hypothesized that faster and better healing can be achieved with rate-varying distractions, as compared with constant-rate distractions. A computational model incorporating the viscoelastic behaviors of the callus tissues and the mechano-regulatory tissue differentiation laws was developed and validated to predict the bone regeneration process during DO. The effect of rate-varying distraction on the healing outcomes (bony bridging time and bone formation) was examined. Compared to the constant low-rate distraction, a low-to-high rate-varying distraction provided a favorable mechanical environment for angiogenesis and bone tissue differentiation, throughout the distraction and consolidation phase, leading to an improved healing outcome with a shortened healing time. These results suggest that a rate-varying clinical strategy could reduce the overall treatment time of DO and decrease the risk of complications related to the external fixator. MDPI 2021-10-29 /pmc/articles/PMC8583714/ /pubmed/34769163 http://dx.doi.org/10.3390/ijms222111734 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Ruisen
Feng, Yili
Bertrand, David
Du, Tianming
Liu, Youjun
Willie, Bettina M.
Yang, Haisheng
Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_full Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_fullStr Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_full_unstemmed Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_short Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study
title_sort enhancing the efficiency of distraction osteogenesis through rate-varying distraction: a computational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583714/
https://www.ncbi.nlm.nih.gov/pubmed/34769163
http://dx.doi.org/10.3390/ijms222111734
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