Cargando…

Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?

Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues. Using polyphenols in counteracting senescence may facilitate the develo...

Descripción completa

Detalles Bibliográficos
Autores principales: Alessio, Nicola, Squillaro, Tiziana, Lettiero, Ida, Galano, Giovanni, De Rosa, Roberto, Peluso, Gianfranco, Galderisi, Umberto, Di Bernardo, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583715/
https://www.ncbi.nlm.nih.gov/pubmed/34769049
http://dx.doi.org/10.3390/ijms222111619
_version_ 1784597270027567104
author Alessio, Nicola
Squillaro, Tiziana
Lettiero, Ida
Galano, Giovanni
De Rosa, Roberto
Peluso, Gianfranco
Galderisi, Umberto
Di Bernardo, Giovanni
author_facet Alessio, Nicola
Squillaro, Tiziana
Lettiero, Ida
Galano, Giovanni
De Rosa, Roberto
Peluso, Gianfranco
Galderisi, Umberto
Di Bernardo, Giovanni
author_sort Alessio, Nicola
collection PubMed
description Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues. Using polyphenols in counteracting senescence may facilitate the development of senotherapeutics given their presence in the human diet, their confirmed tolerability and absence of severe side effects, and their role in preventing senescence and inducing the death of senescent cells. Against that background, we evaluated the effect of piceatannol, a natural polyphenol, on the senescence of mesenchymal stromal cells (MSCs), which play a key role in the body’s homeostasis. Among our results, piceatannol reduced the number of senescent cells both after genotoxic stress that induced acute senescence and in senescent replicative cultures. Such senotherapeutics activity, moreover, promoted the recovery of cell proliferation and the stemness properties of MSCs. Altogether, our findings demonstrate piceatannol’s effectiveness in counteracting senescence by targeting its associated pathways and detecting and affecting P53-dependent and P53-independent senescence. Our study thus suggests that, given piceatannol’s various mechanisms to accomplish its pleiotropic activities, it may be able to counteract any senescent phenotypes.
format Online
Article
Text
id pubmed-8583715
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85837152021-11-12 Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics? Alessio, Nicola Squillaro, Tiziana Lettiero, Ida Galano, Giovanni De Rosa, Roberto Peluso, Gianfranco Galderisi, Umberto Di Bernardo, Giovanni Int J Mol Sci Article Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues. Using polyphenols in counteracting senescence may facilitate the development of senotherapeutics given their presence in the human diet, their confirmed tolerability and absence of severe side effects, and their role in preventing senescence and inducing the death of senescent cells. Against that background, we evaluated the effect of piceatannol, a natural polyphenol, on the senescence of mesenchymal stromal cells (MSCs), which play a key role in the body’s homeostasis. Among our results, piceatannol reduced the number of senescent cells both after genotoxic stress that induced acute senescence and in senescent replicative cultures. Such senotherapeutics activity, moreover, promoted the recovery of cell proliferation and the stemness properties of MSCs. Altogether, our findings demonstrate piceatannol’s effectiveness in counteracting senescence by targeting its associated pathways and detecting and affecting P53-dependent and P53-independent senescence. Our study thus suggests that, given piceatannol’s various mechanisms to accomplish its pleiotropic activities, it may be able to counteract any senescent phenotypes. MDPI 2021-10-27 /pmc/articles/PMC8583715/ /pubmed/34769049 http://dx.doi.org/10.3390/ijms222111619 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alessio, Nicola
Squillaro, Tiziana
Lettiero, Ida
Galano, Giovanni
De Rosa, Roberto
Peluso, Gianfranco
Galderisi, Umberto
Di Bernardo, Giovanni
Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_full Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_fullStr Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_full_unstemmed Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_short Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
title_sort biomolecular evaluation of piceatannol’s effects in counteracting the senescence of mesenchymal stromal cells: a new candidate for senotherapeutics?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583715/
https://www.ncbi.nlm.nih.gov/pubmed/34769049
http://dx.doi.org/10.3390/ijms222111619
work_keys_str_mv AT alessionicola biomolecularevaluationofpiceatannolseffectsincounteractingthesenescenceofmesenchymalstromalcellsanewcandidateforsenotherapeutics
AT squillarotiziana biomolecularevaluationofpiceatannolseffectsincounteractingthesenescenceofmesenchymalstromalcellsanewcandidateforsenotherapeutics
AT lettieroida biomolecularevaluationofpiceatannolseffectsincounteractingthesenescenceofmesenchymalstromalcellsanewcandidateforsenotherapeutics
AT galanogiovanni biomolecularevaluationofpiceatannolseffectsincounteractingthesenescenceofmesenchymalstromalcellsanewcandidateforsenotherapeutics
AT derosaroberto biomolecularevaluationofpiceatannolseffectsincounteractingthesenescenceofmesenchymalstromalcellsanewcandidateforsenotherapeutics
AT pelusogianfranco biomolecularevaluationofpiceatannolseffectsincounteractingthesenescenceofmesenchymalstromalcellsanewcandidateforsenotherapeutics
AT galderisiumberto biomolecularevaluationofpiceatannolseffectsincounteractingthesenescenceofmesenchymalstromalcellsanewcandidateforsenotherapeutics
AT dibernardogiovanni biomolecularevaluationofpiceatannolseffectsincounteractingthesenescenceofmesenchymalstromalcellsanewcandidateforsenotherapeutics