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Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord

(1) Background: Amyotrophic lateral sclerosis (ALS) is an incurable, neurodegenerative disease. In some cases, ALS causes behavioral disturbances and cognitive dysfunction. Swimming has revealed a neuroprotective influence on the motor neurons in ALS. (2) Methods: In the present study, a SOD1-G93A m...

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Autores principales: Dzik, Katarzyna Patrycja, Flis, Damian Józef, Bytowska, Zofia Kinga, Karnia, Mateusz Jakub, Ziolkowski, Wieslaw, Kaczor, Jan Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583724/
https://www.ncbi.nlm.nih.gov/pubmed/34769048
http://dx.doi.org/10.3390/ijms222111614
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author Dzik, Katarzyna Patrycja
Flis, Damian Józef
Bytowska, Zofia Kinga
Karnia, Mateusz Jakub
Ziolkowski, Wieslaw
Kaczor, Jan Jacek
author_facet Dzik, Katarzyna Patrycja
Flis, Damian Józef
Bytowska, Zofia Kinga
Karnia, Mateusz Jakub
Ziolkowski, Wieslaw
Kaczor, Jan Jacek
author_sort Dzik, Katarzyna Patrycja
collection PubMed
description (1) Background: Amyotrophic lateral sclerosis (ALS) is an incurable, neurodegenerative disease. In some cases, ALS causes behavioral disturbances and cognitive dysfunction. Swimming has revealed a neuroprotective influence on the motor neurons in ALS. (2) Methods: In the present study, a SOD1-G93A mice model of ALS were used, with wild-type B6SJL mice as controls. ALS mice were analyzed before ALS onset (10th week of life), at ALS 1 onset (first symptoms of the disease, ALS 1 onset, and ALS 1 onset SWIM), and at terminal ALS (last stage of the disease, ALS TER, and ALS TER SWIM), and compared with wild-type mice. Swim training was applied 5 times per week for 30 min. All mice underwent behavioral tests. The spinal cord was analyzed for the enzyme activities and oxidative stress markers. (3) Results: Pre-symptomatic ALS mice showed increased locomotor activity versus control mice; the swim training reduced these symptoms. The metabolic changes in the spinal cord were present at the pre-symptomatic stage of the disease with a shift towards glycolytic processes at the terminal stage of ALS. Swim training caused an adaptation, resulting in higher glutathione peroxidase (GPx) and protection against oxidative stress. (4) Conclusion: Therapeutic aquatic activity might slow down the progression of ALS.
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spelling pubmed-85837242021-11-12 Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord Dzik, Katarzyna Patrycja Flis, Damian Józef Bytowska, Zofia Kinga Karnia, Mateusz Jakub Ziolkowski, Wieslaw Kaczor, Jan Jacek Int J Mol Sci Article (1) Background: Amyotrophic lateral sclerosis (ALS) is an incurable, neurodegenerative disease. In some cases, ALS causes behavioral disturbances and cognitive dysfunction. Swimming has revealed a neuroprotective influence on the motor neurons in ALS. (2) Methods: In the present study, a SOD1-G93A mice model of ALS were used, with wild-type B6SJL mice as controls. ALS mice were analyzed before ALS onset (10th week of life), at ALS 1 onset (first symptoms of the disease, ALS 1 onset, and ALS 1 onset SWIM), and at terminal ALS (last stage of the disease, ALS TER, and ALS TER SWIM), and compared with wild-type mice. Swim training was applied 5 times per week for 30 min. All mice underwent behavioral tests. The spinal cord was analyzed for the enzyme activities and oxidative stress markers. (3) Results: Pre-symptomatic ALS mice showed increased locomotor activity versus control mice; the swim training reduced these symptoms. The metabolic changes in the spinal cord were present at the pre-symptomatic stage of the disease with a shift towards glycolytic processes at the terminal stage of ALS. Swim training caused an adaptation, resulting in higher glutathione peroxidase (GPx) and protection against oxidative stress. (4) Conclusion: Therapeutic aquatic activity might slow down the progression of ALS. MDPI 2021-10-27 /pmc/articles/PMC8583724/ /pubmed/34769048 http://dx.doi.org/10.3390/ijms222111614 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dzik, Katarzyna Patrycja
Flis, Damian Józef
Bytowska, Zofia Kinga
Karnia, Mateusz Jakub
Ziolkowski, Wieslaw
Kaczor, Jan Jacek
Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord
title Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord
title_full Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord
title_fullStr Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord
title_full_unstemmed Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord
title_short Swim Training Ameliorates Hyperlocomotion of ALS Mice and Increases Glutathione Peroxidase Activity in the Spinal Cord
title_sort swim training ameliorates hyperlocomotion of als mice and increases glutathione peroxidase activity in the spinal cord
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583724/
https://www.ncbi.nlm.nih.gov/pubmed/34769048
http://dx.doi.org/10.3390/ijms222111614
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