Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β(1): Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways

Transforming growth factor-β(1) (TGF-β(1)) occurs at high levels at damage sites of vascular endothelial cell layers and regulates the functions of vascular endothelial cells. Reactive sulfur species (RSS), such as cysteine persulfide, glutathione persulfide, and hydrogen persulfide, are cytoprotect...

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Detalles Bibliográficos
Autores principales: Takahashi, Musubu, Fujie, Tomoya, Nakano, Tsuyoshi, Hara, Takato, Shinkai, Yasuhiro, Takasawa, Ryoko, Hara, Yasushi, Kumagai, Yoshito, Yamamoto, Chika, Kaji, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583730/
https://www.ncbi.nlm.nih.gov/pubmed/34769192
http://dx.doi.org/10.3390/ijms222111762

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