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Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of Bordetella pertussis

The whooping cough agent, Bordetella pertussis, secretes an adenylate cyclase toxin–hemolysin (CyaA, ACT, or AC-Hly) that catalyzes the conversion of intracellular ATP to cAMP and through its signaling annihilates the bactericidal activities of host sentinel phagocytes. In parallel, CyaA permeabiliz...

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Detalles Bibliográficos
Autores principales:	Holubova, Jana, Juhasz, Attila, Masin, Jiri, Stanek, Ondrej, Jurnecka, David, Osickova, Adriana, Sebo, Peter, Osicka, Radim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583748/ https://www.ncbi.nlm.nih.gov/pubmed/34769101 http://dx.doi.org/10.3390/ijms222111655

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