Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor

Semaphorin 4D (Sema4D) is a neurotrophin that is secreted by osteoclasts and binds to its receptor PlexinB1 on osteoblasts to inhibit their differentiation and function. Adenosine A2A activation inhibits osteoclast Sema4D-mediated secretion, diminishes inflammatory osteolysis and prevents bone loss...

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Detalles Bibliográficos
Autores principales: Llamas-Granda, Patricia, Martin-Rodríguez, Laura, Largo, Raquel, Herrero-Beaumont, Gabriel, Mediero, Aránzazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583797/
https://www.ncbi.nlm.nih.gov/pubmed/34768920
http://dx.doi.org/10.3390/ijms222111490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583797/
https://www.ncbi.nlm.nih.gov/pubmed/34768920
http://dx.doi.org/10.3390/ijms222111490

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