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Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor

Semaphorin 4D (Sema4D) is a neurotrophin that is secreted by osteoclasts and binds to its receptor PlexinB1 on osteoblasts to inhibit their differentiation and function. Adenosine A2A activation inhibits osteoclast Sema4D-mediated secretion, diminishes inflammatory osteolysis and prevents bone loss...

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Detalles Bibliográficos
Autores principales:	Llamas-Granda, Patricia, Martin-Rodríguez, Laura, Largo, Raquel, Herrero-Beaumont, Gabriel, Mediero, Aránzazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583797/ https://www.ncbi.nlm.nih.gov/pubmed/34768920 http://dx.doi.org/10.3390/ijms222111490

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