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The Effect of tRNA([Ser]Sec) Isopentenylation on Selenoprotein Expression

Transfer RNA([Ser]Sec) carries multiple post-transcriptional modifications. The A37G mutation in tRNA([Ser]Sec) abrogates isopentenylation of base 37 and has a profound effect on selenoprotein expression in mice. Patients with a homozygous pathogenic p.R323Q variant in tRNA-isopentenyl-transferase (...

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Detalles Bibliográficos
Autores principales:	Fradejas-Villar, Noelia, Bohleber, Simon, Zhao, Wenchao, Reuter, Uschi, Kotter, Annika, Helm, Mark, Knoll, Rainer, McFarland, Robert, Taylor, Robert W., Mo, Yufeng, Miyauchi, Kenjyo, Sakaguchi, Yuriko, Suzuki, Tsutomu, Schweizer, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583801/ https://www.ncbi.nlm.nih.gov/pubmed/34768885 http://dx.doi.org/10.3390/ijms222111454

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