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The Role of Long Non-Coding RNAs in Endometriosis

Endometriosis is a chronic gynecological disorder affecting the quality of life and fertility of many women around the world. Heterogeneous and non-specific symptoms may lead to a delay in diagnosis, with treatment options limited to surgery and hormonal therapy. Hence, there is a need to better und...

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Autores principales: Hudson, Quanah J., Proestling, Katharina, Perricos, Alexandra, Kuessel, Lorenz, Husslein, Heinrich, Wenzl, René, Yotova, Iveta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583837/
https://www.ncbi.nlm.nih.gov/pubmed/34768856
http://dx.doi.org/10.3390/ijms222111425
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author Hudson, Quanah J.
Proestling, Katharina
Perricos, Alexandra
Kuessel, Lorenz
Husslein, Heinrich
Wenzl, René
Yotova, Iveta
author_facet Hudson, Quanah J.
Proestling, Katharina
Perricos, Alexandra
Kuessel, Lorenz
Husslein, Heinrich
Wenzl, René
Yotova, Iveta
author_sort Hudson, Quanah J.
collection PubMed
description Endometriosis is a chronic gynecological disorder affecting the quality of life and fertility of many women around the world. Heterogeneous and non-specific symptoms may lead to a delay in diagnosis, with treatment options limited to surgery and hormonal therapy. Hence, there is a need to better understand the pathogenesis of the disease to improve diagnosis and treatment. Long non-coding RNAs (lncRNAs) have been increasingly shown to be involved in gene regulation but remain relatively under investigated in endometriosis. Mutational and transcriptomic studies have implicated lncRNAs in the pathogenesis of endometriosis. Single-nucleotide polymorphisms (SNPs) in lncRNAs or their regulatory regions have been associated with endometriosis. Genome-wide transcriptomic studies have identified lncRNAs that show deregulated expression in endometriosis, some of which have been subjected to further experiments, which support a role in endometriosis. Mechanistic studies indicate that lncRNAs may regulate genes involved in endometriosis by acting as a molecular sponge for miRNAs, by directly targeting regulatory elements via interactions with chromatin or transcription factors or by affecting signaling pathways. Future studies should concentrate on determining the role of uncharacterized lncRNAs revealed by endometriosis transcriptome studies and the relevance of lncRNAs implicated in the disease by in vitro and animal model studies.
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spelling pubmed-85838372021-11-12 The Role of Long Non-Coding RNAs in Endometriosis Hudson, Quanah J. Proestling, Katharina Perricos, Alexandra Kuessel, Lorenz Husslein, Heinrich Wenzl, René Yotova, Iveta Int J Mol Sci Review Endometriosis is a chronic gynecological disorder affecting the quality of life and fertility of many women around the world. Heterogeneous and non-specific symptoms may lead to a delay in diagnosis, with treatment options limited to surgery and hormonal therapy. Hence, there is a need to better understand the pathogenesis of the disease to improve diagnosis and treatment. Long non-coding RNAs (lncRNAs) have been increasingly shown to be involved in gene regulation but remain relatively under investigated in endometriosis. Mutational and transcriptomic studies have implicated lncRNAs in the pathogenesis of endometriosis. Single-nucleotide polymorphisms (SNPs) in lncRNAs or their regulatory regions have been associated with endometriosis. Genome-wide transcriptomic studies have identified lncRNAs that show deregulated expression in endometriosis, some of which have been subjected to further experiments, which support a role in endometriosis. Mechanistic studies indicate that lncRNAs may regulate genes involved in endometriosis by acting as a molecular sponge for miRNAs, by directly targeting regulatory elements via interactions with chromatin or transcription factors or by affecting signaling pathways. Future studies should concentrate on determining the role of uncharacterized lncRNAs revealed by endometriosis transcriptome studies and the relevance of lncRNAs implicated in the disease by in vitro and animal model studies. MDPI 2021-10-22 /pmc/articles/PMC8583837/ /pubmed/34768856 http://dx.doi.org/10.3390/ijms222111425 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hudson, Quanah J.
Proestling, Katharina
Perricos, Alexandra
Kuessel, Lorenz
Husslein, Heinrich
Wenzl, René
Yotova, Iveta
The Role of Long Non-Coding RNAs in Endometriosis
title The Role of Long Non-Coding RNAs in Endometriosis
title_full The Role of Long Non-Coding RNAs in Endometriosis
title_fullStr The Role of Long Non-Coding RNAs in Endometriosis
title_full_unstemmed The Role of Long Non-Coding RNAs in Endometriosis
title_short The Role of Long Non-Coding RNAs in Endometriosis
title_sort role of long non-coding rnas in endometriosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583837/
https://www.ncbi.nlm.nih.gov/pubmed/34768856
http://dx.doi.org/10.3390/ijms222111425
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