Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy

Parkinson’s disease (PD) is characterized by four pathognomonic hallmarks: (1) motor and non-motor deficits; (2) neuroinflammation and oxidative stress; (3) pathological aggregates of the α-synuclein (α-syn) protein; (4) neurodegeneration of the nigrostriatal system. Recent evidence sustains that th...

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Detalles Bibliográficos
Autores principales: Delgado-Minjares, Karen M., Martinez-Fong, Daniel, Martínez-Dávila, Irma A., Bañuelos, Cecilia, Gutierrez-Castillo, M. E., Blanco-Alvarez, Víctor Manuel, Cardenas-Aguayo, Maria-del-Carmen, Luna-Muñoz, José, Pacheco-Herrero, Mar, Soto-Rojas, Luis O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583859/
https://www.ncbi.nlm.nih.gov/pubmed/34769132
http://dx.doi.org/10.3390/ijms222111702

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