Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?

Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential...

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Autores principales: Rapacka-Zdonczyk, Aleksandra, Wozniak, Agata, Kruszewska, Beata, Waleron, Krzysztof, Grinholc, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583887/
https://www.ncbi.nlm.nih.gov/pubmed/34769009
http://dx.doi.org/10.3390/ijms222111579
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author Rapacka-Zdonczyk, Aleksandra
Wozniak, Agata
Kruszewska, Beata
Waleron, Krzysztof
Grinholc, Mariusz
author_facet Rapacka-Zdonczyk, Aleksandra
Wozniak, Agata
Kruszewska, Beata
Waleron, Krzysztof
Grinholc, Mariusz
author_sort Rapacka-Zdonczyk, Aleksandra
collection PubMed
description Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving E. coli K-12 tolC-, tolA-, umuD-, and recA-deficient mutants revealed some possible mechanisms for aBL tolerance development.
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spelling pubmed-85838872021-11-12 Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment? Rapacka-Zdonczyk, Aleksandra Wozniak, Agata Kruszewska, Beata Waleron, Krzysztof Grinholc, Mariusz Int J Mol Sci Article Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving E. coli K-12 tolC-, tolA-, umuD-, and recA-deficient mutants revealed some possible mechanisms for aBL tolerance development. MDPI 2021-10-27 /pmc/articles/PMC8583887/ /pubmed/34769009 http://dx.doi.org/10.3390/ijms222111579 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rapacka-Zdonczyk, Aleksandra
Wozniak, Agata
Kruszewska, Beata
Waleron, Krzysztof
Grinholc, Mariusz
Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_full Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_fullStr Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_full_unstemmed Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_short Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_sort can gram-negative bacteria develop resistance to antimicrobial blue light treatment?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583887/
https://www.ncbi.nlm.nih.gov/pubmed/34769009
http://dx.doi.org/10.3390/ijms222111579
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