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Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview

Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present a...

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Autores principales: Gullo, Giuseppe, Etrusco, Andrea, Cucinella, Gaspare, Perino, Antonino, Chiantera, Vito, Laganà, Antonio Simone, Tomaiuolo, Rossella, Vitagliano, Amerigo, Giampaolino, Pierluigi, Noventa, Marco, Andrisani, Alessandra, Buzzaccarini, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583899/
https://www.ncbi.nlm.nih.gov/pubmed/34769256
http://dx.doi.org/10.3390/ijms222111825
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author Gullo, Giuseppe
Etrusco, Andrea
Cucinella, Gaspare
Perino, Antonino
Chiantera, Vito
Laganà, Antonio Simone
Tomaiuolo, Rossella
Vitagliano, Amerigo
Giampaolino, Pierluigi
Noventa, Marco
Andrisani, Alessandra
Buzzaccarini, Giovanni
author_facet Gullo, Giuseppe
Etrusco, Andrea
Cucinella, Gaspare
Perino, Antonino
Chiantera, Vito
Laganà, Antonio Simone
Tomaiuolo, Rossella
Vitagliano, Amerigo
Giampaolino, Pierluigi
Noventa, Marco
Andrisani, Alessandra
Buzzaccarini, Giovanni
author_sort Gullo, Giuseppe
collection PubMed
description Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present an overview about the EC fertility-sparing approach state of art. Type I EC at low stage is the only histological type which can be addressed with a fertility-sparing approach. Moreover, no myometrium and/or adnexal invasion should be seen, and lymph-vascular space should not be involved. Regarding the pharmaceutical target, progestins, in particular medroxyprogesterone acetate (MPA) or megestrol acetate (MA), are the most employed agent in conservative treatment of early-stage EC. The metformin usage and hysteroscopic assessment is still under debate, despite promising results. Particularly strict and imperious attention should be given to the follow-up and psychological wellbeing of women, especially because of the double detrimental impairment: both EC and EC-related infertility consequences.
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spelling pubmed-85838992021-11-12 Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview Gullo, Giuseppe Etrusco, Andrea Cucinella, Gaspare Perino, Antonino Chiantera, Vito Laganà, Antonio Simone Tomaiuolo, Rossella Vitagliano, Amerigo Giampaolino, Pierluigi Noventa, Marco Andrisani, Alessandra Buzzaccarini, Giovanni Int J Mol Sci Review Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present an overview about the EC fertility-sparing approach state of art. Type I EC at low stage is the only histological type which can be addressed with a fertility-sparing approach. Moreover, no myometrium and/or adnexal invasion should be seen, and lymph-vascular space should not be involved. Regarding the pharmaceutical target, progestins, in particular medroxyprogesterone acetate (MPA) or megestrol acetate (MA), are the most employed agent in conservative treatment of early-stage EC. The metformin usage and hysteroscopic assessment is still under debate, despite promising results. Particularly strict and imperious attention should be given to the follow-up and psychological wellbeing of women, especially because of the double detrimental impairment: both EC and EC-related infertility consequences. MDPI 2021-10-31 /pmc/articles/PMC8583899/ /pubmed/34769256 http://dx.doi.org/10.3390/ijms222111825 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gullo, Giuseppe
Etrusco, Andrea
Cucinella, Gaspare
Perino, Antonino
Chiantera, Vito
Laganà, Antonio Simone
Tomaiuolo, Rossella
Vitagliano, Amerigo
Giampaolino, Pierluigi
Noventa, Marco
Andrisani, Alessandra
Buzzaccarini, Giovanni
Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_full Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_fullStr Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_full_unstemmed Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_short Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_sort fertility-sparing approach in women affected by stage i and low-grade endometrial carcinoma: an updated overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583899/
https://www.ncbi.nlm.nih.gov/pubmed/34769256
http://dx.doi.org/10.3390/ijms222111825
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