Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts

Glioblastoma (GBM) is one of the deadliest of all human cancers. Developing therapies targeting GBM cancer stem cells or glioma stem cells (GSCs), which are deemed responsible for the malignancy of GBM due to their therapy resistance and tumor-initiating capacity, is considered key to improving the...

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Detalles Bibliográficos
Autores principales: Okada, Masashi, Suzuki, Shuhei, Togashi, Keita, Sugai, Asuka, Yamamoto, Masahiro, Kitanaka, Chifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583947/
https://www.ncbi.nlm.nih.gov/pubmed/34769063
http://dx.doi.org/10.3390/ijms222111633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583947/
https://www.ncbi.nlm.nih.gov/pubmed/34769063
http://dx.doi.org/10.3390/ijms222111633

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