Incorporation of a Nitric Oxide Donating Motif into Novel PC-PLC Inhibitors Provides Enhanced Anti-Proliferative Activity

Inhibition of phosphatidylcholine-specific phospholipase C (PC-PLC) has previously been shown to be a potential target for novel cancer therapeutics. One downstream consequence of PC-PLC activity is the activation of NF-κB, a nuclear transcription factor responsible for transcribing genes related to...

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Detalles Bibliográficos
Autores principales: Rees, Shaun W. P., Rees, Tayla A., Leung, Euphemia, Walker, Christopher S., Barker, David, Pilkington, Lisa I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583960/
https://www.ncbi.nlm.nih.gov/pubmed/34768947
http://dx.doi.org/10.3390/ijms222111518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583960/
https://www.ncbi.nlm.nih.gov/pubmed/34768947
http://dx.doi.org/10.3390/ijms222111518

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