The Role of Oxidative Stress in Sarcoidosis

Sarcoidosis is a rare, systemic inflammatory disease whose diagnosis and management can pose a challenge for clinicians and specialists. Scientific knowledge on the molecular pathways that drive its development is still lacking, with no standardized therapies available and insufficient strategies to...

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Detalles Bibliográficos
Autores principales: Fois, Sara Solveig, Canu, Sara, Fois, Alessandro Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584035/
https://www.ncbi.nlm.nih.gov/pubmed/34769145
http://dx.doi.org/10.3390/ijms222111712
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author Fois, Sara Solveig
Canu, Sara
Fois, Alessandro Giuseppe
author_facet Fois, Sara Solveig
Canu, Sara
Fois, Alessandro Giuseppe
author_sort Fois, Sara Solveig
collection PubMed
description Sarcoidosis is a rare, systemic inflammatory disease whose diagnosis and management can pose a challenge for clinicians and specialists. Scientific knowledge on the molecular pathways that drive its development is still lacking, with no standardized therapies available and insufficient strategies to predict patient outcome. In recent years, oxidative stress has been highlighted as an important factor in the pathogenesis of sarcoidosis, involving several enzymes and molecules in the mechanism of the disease. This review presents current data on the role of oxidative stress in sarcoidosis and its interaction with inflammation, as well as the application of antioxidative therapy in the disease.
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spelling pubmed-85840352021-11-12 The Role of Oxidative Stress in Sarcoidosis Fois, Sara Solveig Canu, Sara Fois, Alessandro Giuseppe Int J Mol Sci Review Sarcoidosis is a rare, systemic inflammatory disease whose diagnosis and management can pose a challenge for clinicians and specialists. Scientific knowledge on the molecular pathways that drive its development is still lacking, with no standardized therapies available and insufficient strategies to predict patient outcome. In recent years, oxidative stress has been highlighted as an important factor in the pathogenesis of sarcoidosis, involving several enzymes and molecules in the mechanism of the disease. This review presents current data on the role of oxidative stress in sarcoidosis and its interaction with inflammation, as well as the application of antioxidative therapy in the disease. MDPI 2021-10-28 /pmc/articles/PMC8584035/ /pubmed/34769145 http://dx.doi.org/10.3390/ijms222111712 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fois, Sara Solveig
Canu, Sara
Fois, Alessandro Giuseppe
The Role of Oxidative Stress in Sarcoidosis
title The Role of Oxidative Stress in Sarcoidosis
title_full The Role of Oxidative Stress in Sarcoidosis
title_fullStr The Role of Oxidative Stress in Sarcoidosis
title_full_unstemmed The Role of Oxidative Stress in Sarcoidosis
title_short The Role of Oxidative Stress in Sarcoidosis
title_sort role of oxidative stress in sarcoidosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584035/
https://www.ncbi.nlm.nih.gov/pubmed/34769145
http://dx.doi.org/10.3390/ijms222111712
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