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Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface

Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into intracellular biochemical messages is termed mechanotransduction. While significant advances in biochemical signaling have been made in the last few...

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Detalles Bibliográficos
Autores principales: Uray, Iván P., Uray, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584042/
https://www.ncbi.nlm.nih.gov/pubmed/34768998
http://dx.doi.org/10.3390/ijms222111566
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author Uray, Iván P.
Uray, Karen
author_facet Uray, Iván P.
Uray, Karen
author_sort Uray, Iván P.
collection PubMed
description Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into intracellular biochemical messages is termed mechanotransduction. While significant advances in biochemical signaling have been made in the last few decades, the role of mechanotransduction in physiological and pathological processes has been largely overlooked until recently. In this review, the role of interactions between the cytoskeleton and cell-cell/cell-matrix adhesions in transducing mechanical signals is discussed. In addition, mechanosensors that reside in the cell membrane and the transduction of mechanical signals to the nucleus are discussed. Finally, we describe two examples in which mechanotransduction plays a significant role in normal physiology and disease development. The first example is the role of mechanotransduction in the proliferation and metastasis of cancerous cells. In this system, the role of mechanotransduction in cellular processes, including proliferation, differentiation, and motility, is described. In the second example, the role of mechanotransduction in a mechanically active organ, the gastrointestinal tract, is described. In the gut, mechanotransduction contributes to normal physiology and the development of motility disorders.
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spelling pubmed-85840422021-11-12 Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface Uray, Iván P. Uray, Karen Int J Mol Sci Review Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually every cell type. The transduction of mechanical messages into intracellular biochemical messages is termed mechanotransduction. While significant advances in biochemical signaling have been made in the last few decades, the role of mechanotransduction in physiological and pathological processes has been largely overlooked until recently. In this review, the role of interactions between the cytoskeleton and cell-cell/cell-matrix adhesions in transducing mechanical signals is discussed. In addition, mechanosensors that reside in the cell membrane and the transduction of mechanical signals to the nucleus are discussed. Finally, we describe two examples in which mechanotransduction plays a significant role in normal physiology and disease development. The first example is the role of mechanotransduction in the proliferation and metastasis of cancerous cells. In this system, the role of mechanotransduction in cellular processes, including proliferation, differentiation, and motility, is described. In the second example, the role of mechanotransduction in a mechanically active organ, the gastrointestinal tract, is described. In the gut, mechanotransduction contributes to normal physiology and the development of motility disorders. MDPI 2021-10-26 /pmc/articles/PMC8584042/ /pubmed/34768998 http://dx.doi.org/10.3390/ijms222111566 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Uray, Iván P.
Uray, Karen
Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_full Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_fullStr Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_full_unstemmed Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_short Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface
title_sort mechanotransduction at the plasma membrane-cytoskeleton interface
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584042/
https://www.ncbi.nlm.nih.gov/pubmed/34768998
http://dx.doi.org/10.3390/ijms222111566
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