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Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats

The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application...

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Autores principales: Tsakanova, Gohar, Babayan, Nelly, Karalova, Elena, Hakobyan, Lina, Abroyan, Liana, Avetisyan, Aida, Avagyan, Hranush, Hakobyan, Sona, Poghosyan, Arpine, Baghdasaryan, Bagrat, Arakelova, Elina, Ayvazyan, Violetta, Matevosyan, Lusine, Navasardyan, Arpine, Davtyan, Hakob, Apresyan, Lilit, Yeremyan, Arsham, Aroutiounian, Rouben, Osipov, Andreyan N., Grigoryan, Bagrat, Karalyan, Zaven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584044/
https://www.ncbi.nlm.nih.gov/pubmed/34768958
http://dx.doi.org/10.3390/ijms222111525
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author Tsakanova, Gohar
Babayan, Nelly
Karalova, Elena
Hakobyan, Lina
Abroyan, Liana
Avetisyan, Aida
Avagyan, Hranush
Hakobyan, Sona
Poghosyan, Arpine
Baghdasaryan, Bagrat
Arakelova, Elina
Ayvazyan, Violetta
Matevosyan, Lusine
Navasardyan, Arpine
Davtyan, Hakob
Apresyan, Lilit
Yeremyan, Arsham
Aroutiounian, Rouben
Osipov, Andreyan N.
Grigoryan, Bagrat
Karalyan, Zaven
author_facet Tsakanova, Gohar
Babayan, Nelly
Karalova, Elena
Hakobyan, Lina
Abroyan, Liana
Avetisyan, Aida
Avagyan, Hranush
Hakobyan, Sona
Poghosyan, Arpine
Baghdasaryan, Bagrat
Arakelova, Elina
Ayvazyan, Violetta
Matevosyan, Lusine
Navasardyan, Arpine
Davtyan, Hakob
Apresyan, Lilit
Yeremyan, Arsham
Aroutiounian, Rouben
Osipov, Andreyan N.
Grigoryan, Bagrat
Karalyan, Zaven
author_sort Tsakanova, Gohar
collection PubMed
description The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application of UPEBs in radiation biology and medicine, the aim of this study was to reveal the changes in immune system in response to low-energy laser-driven UPEB whole-body irradiation in rodents. Forty male albino Wistar rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. The results of this study provide valuable insight into the effect of laser-driven UPEB whole-body irradiation on the immune system of the animals and support further animal experiments on the role of this novel type of irradiation.
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spelling pubmed-85840442021-11-12 Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats Tsakanova, Gohar Babayan, Nelly Karalova, Elena Hakobyan, Lina Abroyan, Liana Avetisyan, Aida Avagyan, Hranush Hakobyan, Sona Poghosyan, Arpine Baghdasaryan, Bagrat Arakelova, Elina Ayvazyan, Violetta Matevosyan, Lusine Navasardyan, Arpine Davtyan, Hakob Apresyan, Lilit Yeremyan, Arsham Aroutiounian, Rouben Osipov, Andreyan N. Grigoryan, Bagrat Karalyan, Zaven Int J Mol Sci Article The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application of UPEBs in radiation biology and medicine, the aim of this study was to reveal the changes in immune system in response to low-energy laser-driven UPEB whole-body irradiation in rodents. Forty male albino Wistar rats were exposed to laser-driven UPEB irradiation, after which different immunological parameters were studied on the 1st, 3rd, 7th, 14th, and 28th day after irradiation. According to the results, this type of irradiation induces alterations in the rat immune system, particularly by increasing the production of pro- and anti-inflammatory cytokines and elevating the DNA damage rate. Moreover, such an immune response reaches its maximal levels on the third day after laser-driven UPEB whole-body irradiation, showing partial recovery on subsequent days with a total recovery on the 28th day. The results of this study provide valuable insight into the effect of laser-driven UPEB whole-body irradiation on the immune system of the animals and support further animal experiments on the role of this novel type of irradiation. MDPI 2021-10-26 /pmc/articles/PMC8584044/ /pubmed/34768958 http://dx.doi.org/10.3390/ijms222111525 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsakanova, Gohar
Babayan, Nelly
Karalova, Elena
Hakobyan, Lina
Abroyan, Liana
Avetisyan, Aida
Avagyan, Hranush
Hakobyan, Sona
Poghosyan, Arpine
Baghdasaryan, Bagrat
Arakelova, Elina
Ayvazyan, Violetta
Matevosyan, Lusine
Navasardyan, Arpine
Davtyan, Hakob
Apresyan, Lilit
Yeremyan, Arsham
Aroutiounian, Rouben
Osipov, Andreyan N.
Grigoryan, Bagrat
Karalyan, Zaven
Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_full Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_fullStr Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_full_unstemmed Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_short Low-Energy Laser-Driven Ultrashort Pulsed Electron Beam Irradiation-Induced Immune Response in Rats
title_sort low-energy laser-driven ultrashort pulsed electron beam irradiation-induced immune response in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584044/
https://www.ncbi.nlm.nih.gov/pubmed/34768958
http://dx.doi.org/10.3390/ijms222111525
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