Cargando…

Novel Insights into the Role of the Mineralocorticoid Receptor in Human Glioblastoma

The majority of glioblastoma (GBM) patients require the administration of dexamethasone (DEXA) to reduce brain inflammation. DEXA activates the glucocorticoid receptor (GR), which can consequently crosstalk with the mineralocorticoid receptor (MR). However, while GR signaling is well studied in GBM,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aldaz, Paula, Fernández-Celis, Amaya, López-Andrés, Natalia, Arozarena, Imanol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584062/ https://www.ncbi.nlm.nih.gov/pubmed/34769089 http://dx.doi.org/10.3390/ijms222111656

Ejemplares similares

Tyrosine Kinase Inhibitors in Adult Glioblastoma: An (Un)Closed Chapter?
por: Aldaz, Paula, et al.
Publicado: (2021)

Biglycan Is a Novel Mineralocorticoid Receptor Target Involved in Aldosterone/Salt-Induced Glomerular Injury
por: Nakamura, Toshifumi, et al.
Publicado: (2022)

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein
por: Jover, Eva, et al.
Publicado: (2021)

Beneficial Effects of Mineralocorticoid Receptor Antagonism on Myocardial Fibrosis in an Experimental Model of the Myxomatous Degeneration of the Mitral Valve
por: Ibarrola, Jaime, et al.
Publicado: (2020)

Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice
por: Palacios-Ramirez, Roberto, et al.
Publicado: (2022)

Novel role for mineralocorticoid receptors in control of a neuronal phenotype
por: McCann, Katharine E., et al.
Publicado: (2019)

A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification
por: Zhu, Dongxing, et al.
Publicado: (2016)

Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology
por: Sevilla, Lisa M., et al.
Publicado: (2018)

Role of Aldosterone and Mineralocorticoid Receptor in Cardiovascular Aging
por: Gorini, Stefania, et al.
Publicado: (2019)

The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology
por: Viengchareun, Say, et al.
Publicado: (2007)

Mechanistic Insights in NeuroD Potentiation of Mineralocorticoid Receptor Signaling
por: van Weert, Lisa T. C. M., et al.
Publicado: (2019)

Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists
por: Pérez-Gordillo, Felipe Luis, et al.
Publicado: (2023)

The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity
por: Gutiérrez-Tenorio, Josué, et al.
Publicado: (2017)

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development
por: Kolkhof, Peter, et al.
Publicado: (2017)

The Time to Reconsider Mineralocorticoid Receptor Blocking Strategy: Arrival of Nonsteroidal Mineralocorticoid Receptor Blockers
por: Tezuka, Yuta, et al.
Publicado: (2022)

Expression of genes encoding mineralocorticoid biosynthetic enzymes and the mineralocorticoid receptor, and levels of mineralocorticoids in the bovine follicle and corpus luteum
por: MUKANGWA, Memory, et al.
Publicado: (2019)

Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy
por: Wellbrock, Claudia, et al.
Publicado: (2015)

The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer
por: Wellbrock, Claudia, et al.
Publicado: (2016)

Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease
por: Parker, Barbara M., et al.
Publicado: (2018)

Mineralocorticoid receptor antagonists: emerging roles in cardiovascular medicine
por: Funder, John W
Publicado: (2013)

OR28-1 Role of Mineralocorticoid Receptor in Metabolic Syndrome
por: Ferguson, Daniel, et al.
Publicado: (2019)

Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor
por: Parasiliti-Caprino, Mirko, et al.
Publicado: (2022)

Mineralocorticoid receptor blockade for renoprotection
por: Cha, Dae Ryong
Publicado: (2018)

Importance of Micromilieu for Pathophysiologic Mineralocorticoid Receptor Activity—When the Mineralocorticoid Receptor Resides in the Wrong Neighborhood
por: Griesler, Bruno, et al.
Publicado: (2022)

Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists
por: Mende, Christian W., et al.
Publicado: (2023)

The glucocorticoid receptor, not the mineralocorticoid receptor, plays the dominant role in adipogenesis and adipokine production in human adipocytes
por: Lee, Mi-Jeong, et al.
Publicado: (2014)

Therapeutic targeting of mineralocorticoid receptors in pulmonary hypertension: Insights from basic research
por: Mamazhakypov, Argen, et al.
Publicado: (2023)

Managing resistant hypertension: focus on mineralocorticoid-receptor antagonists
por: Yugar-Toledo, Juan Carlos, et al.
Publicado: (2017)

Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish
por: Sakamoto, Tatsuya, et al.
Publicado: (2016)

Vascular cell-specific roles of mineralocorticoid receptors in pulmonary hypertension
por: Menon, Divya P., et al.
Publicado: (2021)

The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor
por: Baudrand, Rene, et al.
Publicado: (2018)

Identification of a Dexamethasone Mediated Radioprotection Mechanism Reveals New Therapeutic Vulnerabilities in Glioblastoma
por: Aldaz, Paula, et al.
Publicado: (2021)

Why are mineralocorticoid receptor antagonists cardioprotective?
por: Chai, Wenxia, et al.
Publicado: (2006)

Localization of Mineralocorticoid Receptors at Mammalian Synapses
por: Prager, Eric M., et al.
Publicado: (2010)

Aldosterone and Mineralocorticoid Receptors—Physiology and Pathophysiology
por: Funder, John W.
Publicado: (2017)

Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts
por: Martínez-Martínez, Ernesto, et al.
Publicado: (2017)

The selective mineralocorticoid receptor modulator AZD9977 reveals differences in mineralocorticoid effects of aldosterone and fludrocortisone
por: Bamberg, Krister, et al.
Publicado: (2019)

Interaction of the Mineralocorticoid Receptor With RACK1 and Its Role in Aldosterone Signaling
por: Kuppusamy, Maniselvan, et al.
Publicado: (2017)

The Mineralocorticoid Receptor Plays a Crucial Role in Macrophage Development and Function
por: Faught, Erin, et al.
Publicado: (2023)

Targeting MITF in the tolerance-phase
por: Arozarena, Imanol, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_r1lbma98hhaa2r6nkboasd1d8l