Cargando…

Chronic Exposure to Paraquat Induces Alpha-Synuclein Pathogenic Modifications in Drosophila

Parkinson’s disease (PD) is characterized by the progressive accumulation of neuronal intracellular aggregates largely composed of alpha-Synuclein (αSyn) protein. The process of αSyn aggregation is induced during aging and enhanced by environmental stresses, such as the exposure to pesticides. Paraq...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arsac, Jean-Noël, Sedru, Marianne, Dartiguelongue, Mireille, Vulin, Johann, Davoust, Nathalie, Baron, Thierry, Mollereau, Bertrand
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584077/ https://www.ncbi.nlm.nih.gov/pubmed/34769043 http://dx.doi.org/10.3390/ijms222111613

Ejemplares similares

Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson’s disease
por: Girard, Victor, et al.
Publicado: (2021)

Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity
por: Girard, Victor, et al.
Publicado: (2020)

Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice
por: Naudet, Nicolas, et al.
Publicado: (2017)

Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathy
por: Sargent, Dorian, et al.
Publicado: (2018)

Distinct Transmissibility Features of TSE Sources Derived from Ruminant Prion Diseases by the Oral Route in a Transgenic Mouse Model (TgOvPrP4) Overexpressing the Ovine Prion Protein
por: Arsac, Jean-Noël, et al.
Publicado: (2014)

The p53 control of apoptosis and proliferation: lessons from Drosophila
por: Mollereau, Bertrand, et al.
Publicado: (2014)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification
por: Sugeno, Naoto, et al.
Publicado: (2023)

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina
por: Van Den Brink, Daan M., et al.
Publicado: (2018)

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
por: Gómez-Benito, Mónica, et al.
Publicado: (2020)

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA
por: Bétemps, Dominique, et al.
Publicado: (2014)

Absolute requirement of cholesterol binding for Hedgehog gradient formation in Drosophila
por: Ducuing, Antoine, et al.
Publicado: (2013)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
por: Xiang, Wei, et al.
Publicado: (2015)

Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease
por: Vicente Miranda, Hugo, et al.
Publicado: (2017)

Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders
por: Manzanza, Nelson de Oliveira, et al.
Publicado: (2021)

Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
por: Brembati, Viviana, et al.
Publicado: (2023)

A DPP-mediated feed-forward loop canalizes morphogenesis during Drosophila dorsal closure
por: Ducuing, Antoine, et al.
Publicado: (2015)

Molecular Typing of Protease-Resistant Prion Protein in Transmissible Spongiform Encephalopathies of Small Ruminants, France, 2002–2009
por: Vulin, Johann, et al.
Publicado: (2011)

Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins
por: Vaneyck, Jonathan, et al.
Publicado: (2021)

Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson’s disease
por: Kumar, Ashutosh, et al.
Publicado: (2016)

Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson’s disease
por: Yoo, Hajung, et al.
Publicado: (2022)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

The Tomato/GFP-FLP/FRT Method for Live Imaging of Mosaic Adult Drosophila Photoreceptor Cells
por: Dourlen, Pierre, et al.
Publicado: (2013)

Passive Immunization in Alpha-Synuclein Preclinical Animal Models
por: Folke, Jonas, et al.
Publicado: (2022)

Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
por: Rcom-H'cheo-Gauthier, Alexandre N., et al.
Publicado: (2016)

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
por: Okita, Yuho, et al.
Publicado: (2017)

Cardiac Alpha-Synuclein Is Present in Alpha-Synucleinopathies
por: Javanshiri, Keivan, et al.
Publicado: (2022)

Alpha synuclein in hematopoiesis and immunity
por: Pei, Yu, et al.
Publicado: (2019)

Gastrointestinal Immunity and Alpha-Synuclein
por: Barbut, Denise, et al.
Publicado: (2019)

The Membrane Interaction of Alpha-Synuclein
por: Liu, Cencen, et al.
Publicado: (2021)

Alpha Synuclein: Neurodegeneration and Inflammation
por: Forloni, Gianluigi
Publicado: (2023)

Atypical Bovine Spongiform Encephalopathies, France, 2001–2007
por: Biacabe, Anne-Gaëlle, et al.
Publicado: (2008)

Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli
por: Gerding, Hanne R., et al.
Publicado: (2019)

Ferritin Assembly in Enterocytes of Drosophila melanogaster
por: Rosas-Arellano, Abraham, et al.
Publicado: (2016)

Innate immune responses to paraquat exposure in a Drosophila model of Parkinson’s disease
por: Maitra, Urmila, et al.
Publicado: (2019)

Administration of AAV-Alpha Synuclein NAC Antibody Improves Locomotor Behavior in Rats Overexpressing Alpha Synuclein
por: Chen, Yun-Hsiang, et al.
Publicado: (2021)

Paraquat (Pesticides)
Publicado: (2022)

Alpha-Synuclein Is a Cellular Ferrireductase
por: Davies, Paul, et al.
Publicado: (2011)

Transmission of alpha-synuclein in Parkinson’s disease
por: Lee, Virginia M-Y
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5rcula8eg11oi7br9lne1nno4d