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The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats

As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of...

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Autores principales: Hua, Hanyi, Sheng, Jie, Cui, Yan, Zhang, Wenyi, Hu, Bin, Cheng, Yuliang, Guo, Yahui, Qian, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584096/
https://www.ncbi.nlm.nih.gov/pubmed/34769051
http://dx.doi.org/10.3390/ijms222111620
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author Hua, Hanyi
Sheng, Jie
Cui, Yan
Zhang, Wenyi
Hu, Bin
Cheng, Yuliang
Guo, Yahui
Qian, He
author_facet Hua, Hanyi
Sheng, Jie
Cui, Yan
Zhang, Wenyi
Hu, Bin
Cheng, Yuliang
Guo, Yahui
Qian, He
author_sort Hua, Hanyi
collection PubMed
description As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of aloin on hepatic injury induced by subchronic AFB1 in rats. The result showed that aloin could significantly inhibit the decrease in food intake, body weight growth, immune organ index, and serum albumin content caused by long-term AFB1 exposure. Meanwhile, aloin reduced the level of serum liver function and improved renal swelling and pathological changes of liver tissue. Aloin could also inhibit liver lipid peroxidation and improve liver antioxidant capacity. Further investigation revealed that aloin inhibited the activity and expression of hepatic CYP1A2 and CYP3A4 and down-regulated IL-1β expression in subchronic AFB1-induced liver injury rats. The above study demonstrated that aloin played an important role in blocking or delaying the development process of subchronic AFB1-induced hepatotoxicity. Therefore, aloin is considered to have a potential role as a protective agent against AFB1.
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spelling pubmed-85840962021-11-12 The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats Hua, Hanyi Sheng, Jie Cui, Yan Zhang, Wenyi Hu, Bin Cheng, Yuliang Guo, Yahui Qian, He Int J Mol Sci Article As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of aloin on hepatic injury induced by subchronic AFB1 in rats. The result showed that aloin could significantly inhibit the decrease in food intake, body weight growth, immune organ index, and serum albumin content caused by long-term AFB1 exposure. Meanwhile, aloin reduced the level of serum liver function and improved renal swelling and pathological changes of liver tissue. Aloin could also inhibit liver lipid peroxidation and improve liver antioxidant capacity. Further investigation revealed that aloin inhibited the activity and expression of hepatic CYP1A2 and CYP3A4 and down-regulated IL-1β expression in subchronic AFB1-induced liver injury rats. The above study demonstrated that aloin played an important role in blocking or delaying the development process of subchronic AFB1-induced hepatotoxicity. Therefore, aloin is considered to have a potential role as a protective agent against AFB1. MDPI 2021-10-27 /pmc/articles/PMC8584096/ /pubmed/34769051 http://dx.doi.org/10.3390/ijms222111620 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hua, Hanyi
Sheng, Jie
Cui, Yan
Zhang, Wenyi
Hu, Bin
Cheng, Yuliang
Guo, Yahui
Qian, He
The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_full The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_fullStr The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_full_unstemmed The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_short The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
title_sort intervention and mechanism of action for aloin against subchronic aflatoxin b1 induced hepatic injury in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584096/
https://www.ncbi.nlm.nih.gov/pubmed/34769051
http://dx.doi.org/10.3390/ijms222111620
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