Cargando…

Deciphering the Genomic Landscape and Pharmacological Profile of Uncommon Entities of Adult Rhabdomyosarcomas

Adult rhabdomyosarcoma (RMS) represents an uncommon entity with an incidence of less than 3% of all soft tissue sarcomas (STS). Consequently, the natural history and the clinical management of this disease are infrequently reported. In order to fill this gap, we investigated the molecular biology of...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Vita, Alessandro, Vanni, Silvia, Fausti, Valentina, Cocchi, Claudia, Recine, Federica, Miserocchi, Giacomo, Liverani, Chiara, Spadazzi, Chiara, Bassi, Massimo, Gessaroli, Manlio, Campobassi, Angelo, De Luca, Giovanni, Pieri, Federica, Farnedi, Anna, Franchini, Eugenia, Ferrari, Anna, Domizio, Chiara, Cavagna, Enrico, Gurrieri, Lorena, Bongiovanni, Alberto, Riva, Nada, Calpona, Sebastiano, Di Menna, Giandomenico, Debonis, Silvia Angela, Ibrahim, Toni, Mercatali, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584142/ https://www.ncbi.nlm.nih.gov/pubmed/34768995 http://dx.doi.org/10.3390/ijms222111564

Ejemplares similares

The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient‐derived primary culture case series in tridimensional and zebrafish models
por: De Vita, Alessandro, et al.
Publicado: (2021)

BOne HEalth ManagEment in Patients with Early Breast Cancer: A Retrospective Italian Osteoncology Center “Real-Life” Experience (BOHEME Study)
por: Recine, Federica, et al.
Publicado: (2019)

A Rationale for the Activity of Bone Target Therapy and Tyrosine Kinase Inhibitor Combination in Giant Cell Tumor of Bone and Desmoplastic Fibroma: Translational Evidences
por: De Vita, Alessandro, et al.
Publicado: (2022)

Phase-II Trials of Pazopanib in Metastatic Neuroendocrine Neoplasia (mNEN): A Systematic Review and Meta-Analysis
por: Bongiovanni, Alberto, et al.
Publicado: (2020)

mTOR inhibitor and bone-targeted drugs break the vicious cycle between clear-cell renal carcinoma and osteoclasts in an in vitro co-culture model
por: Spadazzi, Chiara, et al.
Publicado: (2019)

Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas
por: Miserocchi, Giacomo, et al.
Publicado: (2021)

Myxofibrosarcoma landscape: diagnostic pitfalls, clinical management and future perspectives
por: Vanni, Silvia, et al.
Publicado: (2022)

Case Report: Adult NTRK-Rearranged Spindle Cell Neoplasm: Early Tumor Shrinkage in a Case With Bone and Visceral Metastases Treated With Targeted Therapy
por: Recine, Federica, et al.
Publicado: (2022)

Unveiling the Genomic Basis of Chemosensitivity in Sarcomas of the Extremities: An Integrated Approach for an Unmet Clinical Need
por: Vanni, Silvia, et al.
Publicado: (2023)

High-grade transformation of a polymorphous adenocarcinoma of the salivary gland: a case report and review of the literature
por: Miserocchi, Giacomo, et al.
Publicado: (2023)

Characterization and Drug Sensitivity of a New High-Grade Myxofibrosarcoma Cell Line
por: Miserocchi, Giacomo, et al.
Publicado: (2018)

Primary Culture of Undifferentiated Pleomorphic Sarcoma: Molecular Characterization and Response to Anticancer Agents
por: De Vita, Alessandro, et al.
Publicado: (2017)

Primary leiomyosarcoma of the bone: a case report and a review of the literature
por: Recine, Federica, et al.
Publicado: (2017)

The Effect of Everolimus in an In Vitro Model of Triple Negative Breast Cancer and Osteoclasts
por: Mercatali, Laura, et al.
Publicado: (2016)

Management and potentialities of primary cancer cultures in preclinical and translational studies
por: Miserocchi, Giacomo, et al.
Publicado: (2017)

Current classification, treatment options, and new perspectives in the management of adipocytic sarcomas
por: De Vita, Alessandro, et al.
Publicado: (2016)

Metastatic neuroendocrine neoplasia treatments in patients over 70 years of age
por: Bongiovanni, Alberto, et al.
Publicado: (2018)

The emerging role of cancer nanotechnology in the panorama of sarcoma
por: Mercatali, Laura, et al.
Publicado: (2022)

Myxofibrosarcoma primary cultures: molecular and pharmacological profile
por: De Vita, Alessandro, et al.
Publicado: (2017)

Activity of Eribulin in a Primary Culture of Well-Differentiated/Dedifferentiated Adipocytic Sarcoma
por: De Vita, Alessandro, et al.
Publicado: (2016)

Update on the role of trabectedin in the treatment of intractable soft tissue sarcomas
por: Recine, Federica, et al.
Publicado: (2017)

Grading of Neuroendocrine Carcinomas: Correlation of (68)Ga-PET/CT Scan with Tissue Biomarkers
por: Liverani, Chiara, et al.
Publicado: (2018)

Tumor-Stroma Crosstalk in Bone Tissue: The Osteoclastogenic Potential of a Breast Cancer Cell Line in a Co-Culture System and the Role of EGFR Inhibition
por: Mercatali, Laura, et al.
Publicado: (2017)

Precision Medicine in Head and Neck Cancers: Genomic and Preclinical Approaches
por: Miserocchi, Giacomo, et al.
Publicado: (2022)

ALK-negative lung inflammatory myofibroblastic tumor in a young adult: A case report and literature review of molecular alterations
por: Debonis, Silvia Angela, et al.
Publicado: (2021)

Osteoblastic bone metastases from neuroendocrine tumor (NET) of unknown origin detected by (18)fluorocholine PET/CT and its comparison with (68)gallium-DOTATOC PET/CT: Case report and review of the literature
por: Bongiovanni, Alberto, et al.
Publicado: (2017)

HRAS overexpression predicts response to Lenvatinib treatment in gastroenteropancreatic neuroendocrine tumors
por: Liverani, Chiara, et al.
Publicado: (2023)

Immune Checkpoint Inhibitors With or Without Bone-Targeted Therapy in NSCLC Patients With Bone Metastases and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio
por: Bongiovanni, Alberto, et al.
Publicado: (2021)

Development of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model
por: Mercatali, Laura, et al.
Publicado: (2016)

Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model
por: Liverani, Chiara, et al.
Publicado: (2016)

CORRECTION: Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model
por: Liverani, Chiara, et al.
Publicado: (2017)

First prospective data on breast cancer patients from the multicentre italian bone metastasis database
por: Bongiovanni, Alberto, et al.
Publicado: (2021)

Lineage‐specific mechanisms and drivers of breast cancer chemoresistance revealed by 3D biomimetic culture
por: Liverani, Chiara, et al.
Publicado: (2021)

Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer
por: De Vita, Alessandro, et al.
Publicado: (2021)

Systemic Inflammatory Indices in Second-Line Soft Tissue Sarcoma Patients: Focus on Lymphocyte/Monocyte Ratio and Trabectedin
por: Fausti, Valentina, et al.
Publicado: (2023)

Activity and Safety of Immune Checkpoint Inhibitors in Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis
por: Bongiovanni, Alberto, et al.
Publicado: (2021)

Vitamin D receptor polymorphisms or serum levels as key drivers of breast cancer development? The question of the vitamin D pathway
por: Amadori, Dino, et al.
Publicado: (2017)

Perfusion Flow Enhances Viability and Migratory Phenotype in 3D-Cultured Breast Cancer Cells
por: Pasini, Alice, et al.
Publicado: (2021)

Modeling Myxofibrosarcoma: Where Do We Stand and What Is Missing?
por: Lucarelli, Enrico, et al.
Publicado: (2023)

Comment on ‘Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: A nationwide Italian survey’ by Alice Indini et al.
por: Bongiovanni, Alberto, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_foj1a6eghlnjmpq7tsufk9t5k7