Cargando…

Inhibition of Carbonic Anhydrase IX Suppresses Breast Cancer Cell Motility at the Single-Cell Level

Protein Carbonic Anhydrase IX (CA IX), which is expressed in various hypoxic solid tumors in order to maintain proper pH, is also related to cancer cell adhesion, invasion, and metastasis processes. Here, we investigated whether CA IX inhibition by a highly CA IX selective agent benzenesulfonamide V...

Descripción completa

Detalles Bibliográficos
Autores principales:	Janoniene, Agne, Mazutis, Linas, Matulis, Daumantas, Petrikaite, Vilma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584155/ https://www.ncbi.nlm.nih.gov/pubmed/34769000 http://dx.doi.org/10.3390/ijms222111571

Ejemplares similares

New Monoclonal Antibodies for a Selective Detection of Membrane-Associated and Soluble Forms of Carbonic Anhydrase IX in Human Cell Lines and Biological Samples
por: Stravinskiene, Dovile, et al.
Publicado: (2019)

An update on anticancer drug development and delivery targeting carbonic anhydrase IX
por: Kazokaitė, Justina, et al.
Publicado: (2017)

Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures
por: Daunys, Simonas, et al.
Publicado: (2019)

Picomolar fluorescent probes for compound affinity determination to carbonic anhydrase IX expressed in live cancer cells
por: Matulienė, Jurgita, et al.
Publicado: (2022)

Thiazide and other Cl-benzenesulfonamide-bearing clinical drug affinities for human carbonic anhydrases
por: Baranauskiene, Lina, et al.
Publicado: (2021)

Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII
por: Baranauskienė, Lina, et al.
Publicado: (2012)

Structural details of the enzymatic catalysis of carbonic anhydrase II via a mutation of valine to isoleucine
por: Matulis, Daumantas
Publicado: (2020)

Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX
por: Zakšauskas, Audrius, et al.
Publicado: (2021)

Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells
por: Kazokaitė, Justina, et al.
Publicado: (2018)

Titration Calorimetry Standards and the Precision of Isothermal Titration Calorimetry Data
por: Baranauskienė, Lina, et al.
Publicado: (2009)

Intrinsic Solubility of Ionizable Compounds from pK(a) Shift
por: Preikša, Joku̅bas, et al.
Publicado: (2023)

Factors, associated with elevated concentration of soluble carbonic anhydrase IX in plasma of women with cervical dysplasia
por: Grincevičienė, Švitrigailė, et al.
Publicado: (2022)

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding
por: Smirnov, Alexey, et al.
Publicado: (2018)

Carbonic Anhydrase IX Promotes Human Cervical Cancer Cell Motility by Regulating PFKFB4 Expression
por: Hsin, Min-Chieh, et al.
Publicado: (2021)

Thermodynamics of Aryl-Dihydroxyphenyl-Thiadiazole Binding to Human Hsp90
por: Kazlauskas, Egidijus, et al.
Publicado: (2012)

Correction: Thermodynamics of Aryl-Dihydroxyphenyl-Thiadiazole Binding to Human Hsp90
por: Kazlauskas, Egidijus, et al.
Publicado: (2012)

Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
por: Balandis, Benas, et al.
Publicado: (2022)

Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII
por: Morkūnaitė, Vaida, et al.
Publicado: (2014)

Inhibitory Monoclonal Antibodies and Their Recombinant Derivatives Targeting Surface-Exposed Carbonic Anhydrase XII on Cancer Cells
por: Stravinskiene, Dovile, et al.
Publicado: (2020)

Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII
por: Kišonaitė, Miglė, et al.
Publicado: (2014)

Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors
por: Kazokaitė, Justina, et al.
Publicado: (2019)

Carbonic anhydrase IX in oligodendroglial brain tumors
por: Järvelä, Sally, et al.
Publicado: (2008)

Targeting Carbonic Anhydrase IX Activity and Expression
por: Mahon, Brian P., et al.
Publicado: (2015)

Carbonic Anhydrase IX—Mouse versus Human
por: Takacova, Martina, et al.
Publicado: (2019)

Carbonic anhydrase IX and acid transport in cancer
por: Becker, Holger M.
Publicado: (2019)

Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII
por: Smirnovienė, Joana, et al.
Publicado: (2021)

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition
por: Mboge, Mam Y., et al.
Publicado: (2018)

Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells
por: Yang, Jia-Sin, et al.
Publicado: (2017)

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
por: Meleddu, Rita, et al.
Publicado: (2021)

Carbonic Anhydrase IX in Renal Cell Carcinoma, Implications for Disease Management
por: Courcier, Jean, et al.
Publicado: (2020)

Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer
por: Brown-Glaberman, Ursa, et al.
Publicado: (2016)

Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness
por: Ward, Carol, et al.
Publicado: (2018)

Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX
por: Koruza, Katarina, et al.
Publicado: (2020)

Carbonic Anhydrases II, IX, and XII in Reflux Esophagitis
por: Nortunen, Minna, et al.
Publicado: (2021)

Primary Duodenal Adenocarcinoma Expressing Carbonic Anhydrase IX
por: Kubo, Kimitoshi, et al.
Publicado: (2022)

Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts
por: Ditte, Zuzana, et al.
Publicado: (2014)

4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
por: Rutkauskas, Kęstutis, et al.
Publicado: (2014)

Expression and prognostic value of carbonic anhydrase IX (CA-IX) in bladder urothelial carcinoma
por: Xiang, An-Ping, et al.
Publicado: (2022)

The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration
por: Csaderova, Lucia, et al.
Publicado: (2013)

Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma
por: Okuno, Kazuma, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pm4aif4u36bar5ttesnh8k8ksa