Cargando…

Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro

Aggregation of α-synuclein (α-Syn) is implicated in the pathogenesis of Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Therefore, the removal of α-Syn aggregation could lead to the development of many new therapeutic agents for neurodegenerative disease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Inden, Masatoshi, Takagi, Ayaka, Kitai, Hazuki, Ito, Taisei, Kurita, Hisaka, Honda, Ryo, Kamatari, Yuji O., Nozaki, Sora, Wen, Xiaopeng, Hijioka, Masanori, Kitamura, Yoshihisa, Hozumi, Isao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584179/ https://www.ncbi.nlm.nih.gov/pubmed/34768913 http://dx.doi.org/10.3390/ijms222111484

Ejemplares similares

The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells
por: Fujimaki, Ayaka, et al.
Publicado: (2023)

p-Coumaric Acid Has Protective Effects against Mutant Copper–Zinc Superoxide Dismutase 1 via the Activation of Autophagy in N2a Cells
por: Ueda, Tomoyuki, et al.
Publicado: (2019)

Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases
por: Ueda, Tomoyuki, et al.
Publicado: (2020)

The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper–zinc superoxide dismutase 1-mediated toxicity
por: Ito, Taisei, et al.
Publicado: (2020)

Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis
por: Ueda, Tomoyuki, et al.
Publicado: (2022)

MicroRNA-5572 Is a Novel MicroRNA-Regulating SLC30A3 in Sporadic Amyotrophic Lateral Sclerosis
por: Kurita, Hisaka, et al.
Publicado: (2020)

The Novel gem-Dihydroperoxide 12AC3O Suppresses High Phosphate-Induced Calcification via Antioxidant Effects in p53LMAco1 Smooth Muscle Cells
por: Takase, Naoko, et al.
Publicado: (2020)

The effects of Brazilian green propolis that contains flavonols against mutant copper-zinc superoxide dismutase-mediated toxicity
por: Ueda, Tomoyuki, et al.
Publicado: (2017)

Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells
por: Takase, Naoko, et al.
Publicado: (2017)

Hsp70 and Antifibrillogenic Peptides Promote Degradation and Inhibit Intracellular Aggregation of Amyloidogenic Light Chains
por: Dul, Jeanne L., et al.
Publicado: (2001)

Partial reduced Pi transport function of PiT-2 might not be sufficient to induce brain calcification of idiopathic basal ganglia calcification
por: Nishii, Kazuya, et al.
Publicado: (2019)

SLC20A2-Associated Idiopathic Basal Ganglia Calcification-Related Recurrent Psychosis Response to Low-Dose Antipsychotics: A Case Report and Literature Review
por: Uno, Akito, et al.
Publicado: (2020)

Fluorodopa is a Promising Fluorine‐19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease
por: Yanagisawa, Daijiro, et al.
Publicado: (2016)

Spermidine protects against α-synuclein neurotoxicity
por: Büttner, Sabrina, et al.
Publicado: (2014)

Kaempferol and Kaempferol Rhamnosides with Depigmenting and Anti-Inflammatory Properties
por: Rho, Ho Sik, et al.
Publicado: (2011)

Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates
por: Mei, Qinggang, et al.
Publicado: (2015)

Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy
por: Liu, Jia, et al.
Publicado: (2017)

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
por: Roostaee, Alireza, et al.
Publicado: (2013)

N‐homocysteinylation of α‐synuclein promotes its aggregation and neurotoxicity
por: Zhou, Lingyan, et al.
Publicado: (2022)

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
por: Ysselstein, Daniel, et al.
Publicado: (2017)

Seronegative neuromyelitis optica spectrum disorder in primary familial brain calcification with PDGFB variant
por: Biyajima, Masahiro, et al.
Publicado: (2022)

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2011)

Correction: Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2012)

α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity
por: Hu, Zhaoyang, et al.
Publicado: (2016)

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2016)

Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
por: Sarkar, Souvarish, et al.
Publicado: (2021)

Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol
por: Wang, Jingqiu, et al.
Publicado: (2018)

Lipoxin A(4) Receptor Stimulation Attenuates Neuroinflammation in a Mouse Model of Intracerebral Hemorrhage
por: Futokoro, Risa, et al.
Publicado: (2022)

An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain
por: Pacheco, C., et al.
Publicado: (2012)

Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons
por: Tai, Yunchun, et al.
Publicado: (2014)

Blood Plasma of Patients with Parkinson's Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity
por: Wang, Peng, et al.
Publicado: (2016)

Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos
por: Lulla, Aaron, et al.
Publicado: (2016)

Exploring the Structural Diversity in Inhibitors of α-Synuclein Amyloidogenic Folding, Aggregation, and Neurotoxicity
por: Das, Sukanya, et al.
Publicado: (2018)

Non-Cell-Autonomous Neurotoxicity in Parkinson’s Disease Mediated by Astroglial α-Synuclein
por: Chai, MuhChyi, et al.
Publicado: (2019)

Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation
por: Lassen, Louise Berkhoudt, et al.
Publicado: (2022)

A Golgi-targeting fluorescent probe for labile Fe(ii) to reveal an abnormal cellular iron distribution induced by dysfunction of VPS35
por: Hirayama, Tasuku, et al.
Publicado: (2018)

Biosynthesis and engineering of kaempferol in Saccharomyces cerevisiae
por: Duan, Lijin, et al.
Publicado: (2017)

Cardioprotective Properties of Kaempferol: A Review
por: Kamisah, Yusof, et al.
Publicado: (2023)

In vitro anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca
por: Behbahani, M., et al.
Publicado: (2014)

Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
por: Taschenberger, Grit, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_f626srajqm0oot78kagec9843o