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Spontaneous Regression of a Middle Ear Melanoma
To describe a case of complete spontaneous regression of a middle ear melanoma. PATIENT: We present a case of a 68-year-old man with complaints of unilateral hearing loss and an ipsilateral facial nerve paresis. Radiological and histopathological examination revealed a cT4bN0M0 mucosal melanoma of t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584193/ https://www.ncbi.nlm.nih.gov/pubmed/34607999 http://dx.doi.org/10.1097/MAO.0000000000003371 |
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author | Krebbers, Iris Kunst, Henricus P. M. Baijens, Laura W. J. van den Hout, Mari F. C. M. Waterval, Jerome J. |
author_facet | Krebbers, Iris Kunst, Henricus P. M. Baijens, Laura W. J. van den Hout, Mari F. C. M. Waterval, Jerome J. |
author_sort | Krebbers, Iris |
collection | PubMed |
description | To describe a case of complete spontaneous regression of a middle ear melanoma. PATIENT: We present a case of a 68-year-old man with complaints of unilateral hearing loss and an ipsilateral facial nerve paresis. Radiological and histopathological examination revealed a cT4bN0M0 mucosal melanoma of the middle ear. INTERVENTIONS: The patient underwent a subtotal petrosectomy and postoperative radiotherapy. MAIN OUTCOME MEASURE: Computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/computed tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG-PET-CT), and histopathological examination. RESULTS: After subtotal petrosectomy, histopathological examination of the resection specimen showed only fibrosis and a histiocytic and clonal T-cell infiltration, but no residual melanoma at the primary tumor site, consistent with spontaneous tumor regression. Follow-up MRI scanning 6 and 12 months after radiotherapy showed no signs of tumor recurrence. CONCLUSIONS: This case describes the concept of spontaneous regression of a mucosal melanoma of the middle ear. Spontaneous tumor regression at this location has not been described before. |
format | Online Article Text |
id | pubmed-8584193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-85841932021-11-12 Spontaneous Regression of a Middle Ear Melanoma Krebbers, Iris Kunst, Henricus P. M. Baijens, Laura W. J. van den Hout, Mari F. C. M. Waterval, Jerome J. Otol Neurotol Tumors of the Ear and Cranial Base To describe a case of complete spontaneous regression of a middle ear melanoma. PATIENT: We present a case of a 68-year-old man with complaints of unilateral hearing loss and an ipsilateral facial nerve paresis. Radiological and histopathological examination revealed a cT4bN0M0 mucosal melanoma of the middle ear. INTERVENTIONS: The patient underwent a subtotal petrosectomy and postoperative radiotherapy. MAIN OUTCOME MEASURE: Computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/computed tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG-PET-CT), and histopathological examination. RESULTS: After subtotal petrosectomy, histopathological examination of the resection specimen showed only fibrosis and a histiocytic and clonal T-cell infiltration, but no residual melanoma at the primary tumor site, consistent with spontaneous tumor regression. Follow-up MRI scanning 6 and 12 months after radiotherapy showed no signs of tumor recurrence. CONCLUSIONS: This case describes the concept of spontaneous regression of a mucosal melanoma of the middle ear. Spontaneous tumor regression at this location has not been described before. Lippincott Williams & Wilkins 2021-12 2021-09-30 /pmc/articles/PMC8584193/ /pubmed/34607999 http://dx.doi.org/10.1097/MAO.0000000000003371 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of Otology & Neurotology, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Tumors of the Ear and Cranial Base Krebbers, Iris Kunst, Henricus P. M. Baijens, Laura W. J. van den Hout, Mari F. C. M. Waterval, Jerome J. Spontaneous Regression of a Middle Ear Melanoma |
title | Spontaneous Regression of a Middle Ear Melanoma |
title_full | Spontaneous Regression of a Middle Ear Melanoma |
title_fullStr | Spontaneous Regression of a Middle Ear Melanoma |
title_full_unstemmed | Spontaneous Regression of a Middle Ear Melanoma |
title_short | Spontaneous Regression of a Middle Ear Melanoma |
title_sort | spontaneous regression of a middle ear melanoma |
topic | Tumors of the Ear and Cranial Base |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584193/ https://www.ncbi.nlm.nih.gov/pubmed/34607999 http://dx.doi.org/10.1097/MAO.0000000000003371 |
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