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Spontaneous Regression of a Middle Ear Melanoma

To describe a case of complete spontaneous regression of a middle ear melanoma. PATIENT: We present a case of a 68-year-old man with complaints of unilateral hearing loss and an ipsilateral facial nerve paresis. Radiological and histopathological examination revealed a cT4bN0M0 mucosal melanoma of t...

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Autores principales: Krebbers, Iris, Kunst, Henricus P. M., Baijens, Laura W. J., van den Hout, Mari F. C. M., Waterval, Jerome J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584193/
https://www.ncbi.nlm.nih.gov/pubmed/34607999
http://dx.doi.org/10.1097/MAO.0000000000003371
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author Krebbers, Iris
Kunst, Henricus P. M.
Baijens, Laura W. J.
van den Hout, Mari F. C. M.
Waterval, Jerome J.
author_facet Krebbers, Iris
Kunst, Henricus P. M.
Baijens, Laura W. J.
van den Hout, Mari F. C. M.
Waterval, Jerome J.
author_sort Krebbers, Iris
collection PubMed
description To describe a case of complete spontaneous regression of a middle ear melanoma. PATIENT: We present a case of a 68-year-old man with complaints of unilateral hearing loss and an ipsilateral facial nerve paresis. Radiological and histopathological examination revealed a cT4bN0M0 mucosal melanoma of the middle ear. INTERVENTIONS: The patient underwent a subtotal petrosectomy and postoperative radiotherapy. MAIN OUTCOME MEASURE: Computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/computed tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG-PET-CT), and histopathological examination. RESULTS: After subtotal petrosectomy, histopathological examination of the resection specimen showed only fibrosis and a histiocytic and clonal T-cell infiltration, but no residual melanoma at the primary tumor site, consistent with spontaneous tumor regression. Follow-up MRI scanning 6 and 12 months after radiotherapy showed no signs of tumor recurrence. CONCLUSIONS: This case describes the concept of spontaneous regression of a mucosal melanoma of the middle ear. Spontaneous tumor regression at this location has not been described before.
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spelling pubmed-85841932021-11-12 Spontaneous Regression of a Middle Ear Melanoma Krebbers, Iris Kunst, Henricus P. M. Baijens, Laura W. J. van den Hout, Mari F. C. M. Waterval, Jerome J. Otol Neurotol Tumors of the Ear and Cranial Base To describe a case of complete spontaneous regression of a middle ear melanoma. PATIENT: We present a case of a 68-year-old man with complaints of unilateral hearing loss and an ipsilateral facial nerve paresis. Radiological and histopathological examination revealed a cT4bN0M0 mucosal melanoma of the middle ear. INTERVENTIONS: The patient underwent a subtotal petrosectomy and postoperative radiotherapy. MAIN OUTCOME MEASURE: Computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/computed tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG-PET-CT), and histopathological examination. RESULTS: After subtotal petrosectomy, histopathological examination of the resection specimen showed only fibrosis and a histiocytic and clonal T-cell infiltration, but no residual melanoma at the primary tumor site, consistent with spontaneous tumor regression. Follow-up MRI scanning 6 and 12 months after radiotherapy showed no signs of tumor recurrence. CONCLUSIONS: This case describes the concept of spontaneous regression of a mucosal melanoma of the middle ear. Spontaneous tumor regression at this location has not been described before. Lippincott Williams & Wilkins 2021-12 2021-09-30 /pmc/articles/PMC8584193/ /pubmed/34607999 http://dx.doi.org/10.1097/MAO.0000000000003371 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of Otology & Neurotology, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Tumors of the Ear and Cranial Base
Krebbers, Iris
Kunst, Henricus P. M.
Baijens, Laura W. J.
van den Hout, Mari F. C. M.
Waterval, Jerome J.
Spontaneous Regression of a Middle Ear Melanoma
title Spontaneous Regression of a Middle Ear Melanoma
title_full Spontaneous Regression of a Middle Ear Melanoma
title_fullStr Spontaneous Regression of a Middle Ear Melanoma
title_full_unstemmed Spontaneous Regression of a Middle Ear Melanoma
title_short Spontaneous Regression of a Middle Ear Melanoma
title_sort spontaneous regression of a middle ear melanoma
topic Tumors of the Ear and Cranial Base
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584193/
https://www.ncbi.nlm.nih.gov/pubmed/34607999
http://dx.doi.org/10.1097/MAO.0000000000003371
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