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A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection condit...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584228/ https://www.ncbi.nlm.nih.gov/pubmed/34769218 http://dx.doi.org/10.3390/ijms222111787 |
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author | Sanie-Jahromi, Fatemeh NejatyJahromy, Yaser Jahromi, Rahim Raoofi |
author_facet | Sanie-Jahromi, Fatemeh NejatyJahromy, Yaser Jahromi, Rahim Raoofi |
author_sort | Sanie-Jahromi, Fatemeh |
collection | PubMed |
description | Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection conditions of COVID-19. In this study, we first provide a review of recent reports of COVID-19 clinical outcomes in children and pregnant women. We then suggest a mechanism that explains the curious case of COVID-19 in children/pregnant women. The unique stem cell molecular signature, as well as the very low expression of angiotensin-converting enzyme 2 and the lower ACE/ACE2 ratio in stem cells of children/pregnant women compared to adults might be the cause of milder symptoms of COVID-19 in them. This study provides the main molecular keys on how stem cells can function properly and exert their immunomodulatory and regenerative effects in COVID-19-infected children/pregnant women, while failing to replicate their role in adults. This can lay the groundwork for both predicting the pattern of spread and severity of the symptoms in a population and designing novel stem cell-based treatment and prevention strategies for COVID-19. |
format | Online Article Text |
id | pubmed-8584228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85842282021-11-12 A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women Sanie-Jahromi, Fatemeh NejatyJahromy, Yaser Jahromi, Rahim Raoofi Int J Mol Sci Review Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection conditions of COVID-19. In this study, we first provide a review of recent reports of COVID-19 clinical outcomes in children and pregnant women. We then suggest a mechanism that explains the curious case of COVID-19 in children/pregnant women. The unique stem cell molecular signature, as well as the very low expression of angiotensin-converting enzyme 2 and the lower ACE/ACE2 ratio in stem cells of children/pregnant women compared to adults might be the cause of milder symptoms of COVID-19 in them. This study provides the main molecular keys on how stem cells can function properly and exert their immunomodulatory and regenerative effects in COVID-19-infected children/pregnant women, while failing to replicate their role in adults. This can lay the groundwork for both predicting the pattern of spread and severity of the symptoms in a population and designing novel stem cell-based treatment and prevention strategies for COVID-19. MDPI 2021-10-30 /pmc/articles/PMC8584228/ /pubmed/34769218 http://dx.doi.org/10.3390/ijms222111787 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sanie-Jahromi, Fatemeh NejatyJahromy, Yaser Jahromi, Rahim Raoofi A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women |
title | A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women |
title_full | A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women |
title_fullStr | A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women |
title_full_unstemmed | A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women |
title_short | A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women |
title_sort | review on the role of stem cells against sars-cov-2 in children and pregnant women |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584228/ https://www.ncbi.nlm.nih.gov/pubmed/34769218 http://dx.doi.org/10.3390/ijms222111787 |
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