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A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women

Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection condit...

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Autores principales: Sanie-Jahromi, Fatemeh, NejatyJahromy, Yaser, Jahromi, Rahim Raoofi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584228/
https://www.ncbi.nlm.nih.gov/pubmed/34769218
http://dx.doi.org/10.3390/ijms222111787
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author Sanie-Jahromi, Fatemeh
NejatyJahromy, Yaser
Jahromi, Rahim Raoofi
author_facet Sanie-Jahromi, Fatemeh
NejatyJahromy, Yaser
Jahromi, Rahim Raoofi
author_sort Sanie-Jahromi, Fatemeh
collection PubMed
description Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection conditions of COVID-19. In this study, we first provide a review of recent reports of COVID-19 clinical outcomes in children and pregnant women. We then suggest a mechanism that explains the curious case of COVID-19 in children/pregnant women. The unique stem cell molecular signature, as well as the very low expression of angiotensin-converting enzyme 2 and the lower ACE/ACE2 ratio in stem cells of children/pregnant women compared to adults might be the cause of milder symptoms of COVID-19 in them. This study provides the main molecular keys on how stem cells can function properly and exert their immunomodulatory and regenerative effects in COVID-19-infected children/pregnant women, while failing to replicate their role in adults. This can lay the groundwork for both predicting the pattern of spread and severity of the symptoms in a population and designing novel stem cell-based treatment and prevention strategies for COVID-19.
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spelling pubmed-85842282021-11-12 A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women Sanie-Jahromi, Fatemeh NejatyJahromy, Yaser Jahromi, Rahim Raoofi Int J Mol Sci Review Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection conditions of COVID-19. In this study, we first provide a review of recent reports of COVID-19 clinical outcomes in children and pregnant women. We then suggest a mechanism that explains the curious case of COVID-19 in children/pregnant women. The unique stem cell molecular signature, as well as the very low expression of angiotensin-converting enzyme 2 and the lower ACE/ACE2 ratio in stem cells of children/pregnant women compared to adults might be the cause of milder symptoms of COVID-19 in them. This study provides the main molecular keys on how stem cells can function properly and exert their immunomodulatory and regenerative effects in COVID-19-infected children/pregnant women, while failing to replicate their role in adults. This can lay the groundwork for both predicting the pattern of spread and severity of the symptoms in a population and designing novel stem cell-based treatment and prevention strategies for COVID-19. MDPI 2021-10-30 /pmc/articles/PMC8584228/ /pubmed/34769218 http://dx.doi.org/10.3390/ijms222111787 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sanie-Jahromi, Fatemeh
NejatyJahromy, Yaser
Jahromi, Rahim Raoofi
A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_full A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_fullStr A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_full_unstemmed A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_short A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_sort review on the role of stem cells against sars-cov-2 in children and pregnant women
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584228/
https://www.ncbi.nlm.nih.gov/pubmed/34769218
http://dx.doi.org/10.3390/ijms222111787
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