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The 3D Genome: From Structure to Function

The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled u...

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Detalles Bibliográficos
Autores principales: Mohanta, Tapan Kumar, Mishra, Awdhesh Kumar, Al-Harrasi, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584255/
https://www.ncbi.nlm.nih.gov/pubmed/34769016
http://dx.doi.org/10.3390/ijms222111585
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author Mohanta, Tapan Kumar
Mishra, Awdhesh Kumar
Al-Harrasi, Ahmed
author_facet Mohanta, Tapan Kumar
Mishra, Awdhesh Kumar
Al-Harrasi, Ahmed
author_sort Mohanta, Tapan Kumar
collection PubMed
description The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled us to understand the 3D spatial organization of the genome. Chromosome capture methods using a ligation approach and the visualization tool of a 3D genome browser have facilitated detailed exploration of the genome. Topologically associated domains (TADs), lamin-associated domains, CCCTC-binding factor domains, cohesin, and chromatin structures are the prominent identified components that encode the 3D structure of the genome. Although TADs are the major contributors to 3D genome organization, they are absent in Arabidopsis. However, a few research groups have reported the presence of TAD-like structures in the plant kingdom.
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spelling pubmed-85842552021-11-12 The 3D Genome: From Structure to Function Mohanta, Tapan Kumar Mishra, Awdhesh Kumar Al-Harrasi, Ahmed Int J Mol Sci Review The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled us to understand the 3D spatial organization of the genome. Chromosome capture methods using a ligation approach and the visualization tool of a 3D genome browser have facilitated detailed exploration of the genome. Topologically associated domains (TADs), lamin-associated domains, CCCTC-binding factor domains, cohesin, and chromatin structures are the prominent identified components that encode the 3D structure of the genome. Although TADs are the major contributors to 3D genome organization, they are absent in Arabidopsis. However, a few research groups have reported the presence of TAD-like structures in the plant kingdom. MDPI 2021-10-27 /pmc/articles/PMC8584255/ /pubmed/34769016 http://dx.doi.org/10.3390/ijms222111585 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mohanta, Tapan Kumar
Mishra, Awdhesh Kumar
Al-Harrasi, Ahmed
The 3D Genome: From Structure to Function
title The 3D Genome: From Structure to Function
title_full The 3D Genome: From Structure to Function
title_fullStr The 3D Genome: From Structure to Function
title_full_unstemmed The 3D Genome: From Structure to Function
title_short The 3D Genome: From Structure to Function
title_sort 3d genome: from structure to function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584255/
https://www.ncbi.nlm.nih.gov/pubmed/34769016
http://dx.doi.org/10.3390/ijms222111585
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