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The 3D Genome: From Structure to Function
The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled u...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584255/ https://www.ncbi.nlm.nih.gov/pubmed/34769016 http://dx.doi.org/10.3390/ijms222111585 |
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author | Mohanta, Tapan Kumar Mishra, Awdhesh Kumar Al-Harrasi, Ahmed |
author_facet | Mohanta, Tapan Kumar Mishra, Awdhesh Kumar Al-Harrasi, Ahmed |
author_sort | Mohanta, Tapan Kumar |
collection | PubMed |
description | The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled us to understand the 3D spatial organization of the genome. Chromosome capture methods using a ligation approach and the visualization tool of a 3D genome browser have facilitated detailed exploration of the genome. Topologically associated domains (TADs), lamin-associated domains, CCCTC-binding factor domains, cohesin, and chromatin structures are the prominent identified components that encode the 3D structure of the genome. Although TADs are the major contributors to 3D genome organization, they are absent in Arabidopsis. However, a few research groups have reported the presence of TAD-like structures in the plant kingdom. |
format | Online Article Text |
id | pubmed-8584255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85842552021-11-12 The 3D Genome: From Structure to Function Mohanta, Tapan Kumar Mishra, Awdhesh Kumar Al-Harrasi, Ahmed Int J Mol Sci Review The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled us to understand the 3D spatial organization of the genome. Chromosome capture methods using a ligation approach and the visualization tool of a 3D genome browser have facilitated detailed exploration of the genome. Topologically associated domains (TADs), lamin-associated domains, CCCTC-binding factor domains, cohesin, and chromatin structures are the prominent identified components that encode the 3D structure of the genome. Although TADs are the major contributors to 3D genome organization, they are absent in Arabidopsis. However, a few research groups have reported the presence of TAD-like structures in the plant kingdom. MDPI 2021-10-27 /pmc/articles/PMC8584255/ /pubmed/34769016 http://dx.doi.org/10.3390/ijms222111585 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mohanta, Tapan Kumar Mishra, Awdhesh Kumar Al-Harrasi, Ahmed The 3D Genome: From Structure to Function |
title | The 3D Genome: From Structure to Function |
title_full | The 3D Genome: From Structure to Function |
title_fullStr | The 3D Genome: From Structure to Function |
title_full_unstemmed | The 3D Genome: From Structure to Function |
title_short | The 3D Genome: From Structure to Function |
title_sort | 3d genome: from structure to function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584255/ https://www.ncbi.nlm.nih.gov/pubmed/34769016 http://dx.doi.org/10.3390/ijms222111585 |
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