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Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central...

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Autores principales: Albanese, Maria, Di Girolamo, Stefano, Silvani, Lorenzo, Ciaschi, Eleonora, Chiaramonte, Barbara, Conti, Matteo, Passali, Francesco Maria, Di Gioia, Battista, Mercuri, Nicola Biagio, Di Stadio, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584263/
https://www.ncbi.nlm.nih.gov/pubmed/34768526
http://dx.doi.org/10.3390/jcm10215007
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author Albanese, Maria
Di Girolamo, Stefano
Silvani, Lorenzo
Ciaschi, Eleonora
Chiaramonte, Barbara
Conti, Matteo
Passali, Francesco Maria
Di Gioia, Battista
Mercuri, Nicola Biagio
Di Stadio, Arianna
author_facet Albanese, Maria
Di Girolamo, Stefano
Silvani, Lorenzo
Ciaschi, Eleonora
Chiaramonte, Barbara
Conti, Matteo
Passali, Francesco Maria
Di Gioia, Battista
Mercuri, Nicola Biagio
Di Stadio, Arianna
author_sort Albanese, Maria
collection PubMed
description Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination; self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time.
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spelling pubmed-85842632021-11-12 Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study Albanese, Maria Di Girolamo, Stefano Silvani, Lorenzo Ciaschi, Eleonora Chiaramonte, Barbara Conti, Matteo Passali, Francesco Maria Di Gioia, Battista Mercuri, Nicola Biagio Di Stadio, Arianna J Clin Med Article Although several cochleo-vestibular symptoms are commonly associated with migraine, only a limited number of studies have been done in this regard. Some reported abnormalities in audiometry, auditory brainstem response and vestibular tests, considering these manifestations mainly related to central etiology. However, increasing evidence also suggests a peripheral involvement of the inner ear in migraine. The aim of this study was to investigate the peripheral auditory pathway in migraineurs using otoacoustic emissions (OAEs), to detect alteration of cochlear functioning and possible relationship with disease severity. Sixty-two migraineurs and sixty matched controls were enrolled in the study and underwent a routine neuro-otolaryngology examination; self-administered questionnaires were used to evaluate subjective perception of hearing disability. DPOAE and their suppression were lower in migraineurs compared to controls and significantly related to the disease duration. Altered DPOAE exposed migraineurs to the risk of affecting by migraine without aura, of presenting with ocular and/or auditory symptoms during attack and of using more painkillers. Concomitant dopaminergic symptoms and/or allodynia such as the acute non-consumption of triptans were significant determinants of decreased contralateral suppression of DPOAE among migraineurs. This potential subclinical cochlear impairment in migraine detected by OAEs may represent the earliest sign of sensorineural damage in these patients, providing a promising tool for the initial diagnosis and an opportunity to monitor disease course and treatment response over time. MDPI 2021-10-27 /pmc/articles/PMC8584263/ /pubmed/34768526 http://dx.doi.org/10.3390/jcm10215007 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Albanese, Maria
Di Girolamo, Stefano
Silvani, Lorenzo
Ciaschi, Eleonora
Chiaramonte, Barbara
Conti, Matteo
Passali, Francesco Maria
Di Gioia, Battista
Mercuri, Nicola Biagio
Di Stadio, Arianna
Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_full Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_fullStr Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_full_unstemmed Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_short Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study
title_sort distortion product otoacoustic emissions and their suppression as predictors of peripheral auditory damage in migraine: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584263/
https://www.ncbi.nlm.nih.gov/pubmed/34768526
http://dx.doi.org/10.3390/jcm10215007
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