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Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D(3) Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Two 24-fluoro-25-hydroxyvitamin D(3) analogues (3,4) were synthesized in a convergent manner. The introduction of a stereocenter to the vitamin D(3) side-chain C24 position was achieved via Sharpless dihydroxylation, and a deoxyfluorination reaction was utilized for the fluorination step. Comparison...

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Detalles Bibliográficos
Autores principales:	Kawagoe, Fumihiro, Mototani, Sayuri, Yasuda, Kaori, Mano, Hiroki, Sakaki, Toshiyuki, Kittaka, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584271/ https://www.ncbi.nlm.nih.gov/pubmed/34769295 http://dx.doi.org/10.3390/ijms222111863

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